GIVAUDAN-KARRER LECTURES – 2013

University of Illinois, Urbana-Champaign, Illinois, USA

Research in the Denmark Group involves the interplay of structure, reactivity and mechanism in service of the development and application of new synthetic reactions. Stereochemistry and catalysis form the pillars upon which many research programs rest, such as in enantioselective Lewis base catalysis, phase transfer catalysis and transition metal catalysis.

Topics in this Lecture Series will include

I. Concepts and Mechanisms of Catalysis

II. Catalytic, Enantioselective Synthesis

III. Asymmetric Transformations

IV. Cheminformatics

Professor Scott Denmark
University of Zurich, Irchel Campus
Office Y11-G-13

Lecture 1 – Characteristics of Catalysis: Basic Principles and Historical Survey

Lecture 2 – Mechanism of Catalysis: Lewis Acid Catalysis

Lecture 3 – Mechanisms of Catalysis: Lewis Base Catalysis

Lecture 4 – Mechanisms of Catalysis: Brønsted Acid Catalysis

Lecture 5 – Mechanisms of Catalysis: Brønsted Base Catalysis

Lecture 6  Mechanisms of Catalysis: Ion Pairing, Anion Binding Catalysis

Lecture 7 – Kinetic Resolution: Principles and Applications

Lecture 8 – Dynamic Kinetic Resolution and Dynamic Asymmetric Transformation

Lecture 9 – Asymmetric Catalysis with Chiral Lewis Bases, Part 1: Concepts, Illustrations in the Chemistry of Group 14 Elements.

Lecture 10 – Asymmetric Catalysis with Chiral Lewis Bases, Part 2: Illustrations in the Chemistry of Group 13, 16 and 17 Elements

Lecture 11 – Design and Development of Asymmetric Phase Transfer Catalysts Guided by Chemoinformatics.

Lecture 12 – Silicon-Based Cross-Coupling Reactions: A Practical Alternative to Boron- and Tin-Based Methods.