Publications

Selected References:

PubMed link to the selected publications

Nazaruk E, Gorecka E, Osornio YM, Landau EM, Bilewicz, R. Charged additives modify drug release rates from lipidic cubic phase carriers by modulating electrostatic interactions. J. Electroanal. Chem. in press

Gottwald E, Schuh C, Haenni D, Ghazi S, Bugarski, M, Duss M, Landau EM, Kaech A, Ziegler U, Lundby A, Lundby C, Hall A.  The Iron Chelator Deferasirox Causes Kidney Disease via Mitochondrial Toxicity. J. Clin. Investig. Submitted

Zabara A, Meikle TG, Trenker R, Yao S, Newman J, Peat TS, Separovic F, Conn CE, Call MJ, Call ME, Landau EM, Drummond CJ. Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Structure, Mesophase Properties, and Crystallogenesis. Cryst. Growth Des, In press

Jablonowska E, Nazaruk, E, Matyszewska, D, Speziale, C, Mezzenga, R, Landau, EM, Bilewicz, R. Interactions of lipidic cubic phase nanoparticles with lipid membranes. Langmuir. 2016 Sep 20; 32 (37):9640-8. doi:10.1021/acs.langmuir.6b01746. Epub 2016 Aug 31.

Speziale C, Salvati Manni L, Manatschal C, Landau EM, Mezzenga R. A macroscopic H+ and Cl- ions pump via reconstitution of EcClC membrane proteins in lipidic cubic mesophases. Proc Natl Acad Sci USA. 2016 July 5; 113 (27):7491-6 doi: 10.1073/pnas.1603965113. Epub 2016 June 16.

Nazaruk E, Miszta P, Filipek SH, Gorecka E, Landau EM, Bilewicz R. Lyotropic cubic phases for drug delivery: diffusion and sustained release from the mesophase evaluated by electrochemical methods. Langmuir. 2015 Nov 24; 31(46):12753-61. doi: 10.1021/acs.langmuir.5b03247. Epub 2015 Nov 10

Aleandri S, Bandera D, Mezzenga R, Landau EM. Biotinylated cubosomes: a versatile tool for active targeting and codelivery of paclitaxel and a fluorescein-based lipid dye. Langmuir, 2015 Nov 24; 31(46):12770–6. doi: 10.1021/acs.langmuir.5b03469. Epub 2015 Nov 10

Aleandri S, Speziale C, Mezzenga R, Landau EM. Design of light-triggered lyotropic liquid crystal mesophases and their application as molecular switches in “on demand” release. Langmuir. 2015 Jun 30;31(25):6981-7. doi: 10.1021/acs.langmuir.5b01945. Epub 2015 Jun 19.

Salvati Manni L, Zabara A, Osornio YM, Schöppe J, Batyuk A, Plückthun A, Siegel JS, Mezzenga R, Landau EM. Phase behavior of a designed cyclopropyl analogue of monoolein: Implications for low-temperature membrane protein crystallization. Angew Chem Int Ed Engl. 2015 Jan 12;54(3):1027-1031. doi: 10.1002/anie.201409791. Epub 2014 Nov 21.

Rahanyan-Kägi N, Aleandri S, Speziale C, Mezzenga R, Landau EM. Stimuli-responsive lipidic cubic phase: Triggered release and sequestration of guest molecules. Chemistry. 2015 Jan 26;21(5):1873-7. doi: 10.1002/chem.201405580. Epub 2014 Dec 15.

Matyszewska D, Sek S, Jabłonowska E, Pałys B, Pawlowski J, Bilewicz R, Konrad F, Osornio YM, Landau EM. Dependence of interfacial film organization on lipid molecular structure. Langmuir. 2014 Aug 29;30 (38):11329–39. doi: 10.1021/la502092g.

Nazaruk E, Landau EM Bilewicz R. Membrane bound enzyme hosted in liquid crystalline cubic phase for sensing and fuel cells. Electrochim. Acta. 2014 Sep 10; 140: 96-100. doi: 10.1016/j.electacta.2014.05.130.

Nazaruk E, Szlęzak M, Górecka E, Bilewicz R, Osornio YM, Uebelhart P, Landau EM. Design and assembly of pH-sensitive lipidic cubic phase matrices for drug release. Langmuir. 2014 Feb 11; 30 (5): 1383–90. doi: 10.1021/la403694e.

Mattarella M, Haberl JM, Ruokolainen J, Landau EM, Mezzenga R, Siegel JS. Five-fold symmetric penta-substituted corannulene with gelation properties and a liquid-crystalline phase.Chem Commun (Camb). 2013 Aug 21;49(65):7204-6. doi: 10.1039/c3cc41476k.PMID: 23842476.

Komisarski M, Osornio YM, Siegel JS, Landau EM. Tailored Host-Guest Lipidic Cubic Phases: A Protocell Model Exhibiting Nucleic Acid Recognition. Chemistry. 2013 Jan 21;19(4):1262-7. doi: 10.1002/chem.201203372.

Osornio YM, Uebelhart P, Bosshard S, Konrad F, Siegel JS, Landau EM. Design and synthesis of lipids for the fabrication of functional lipidic cubic-phase biomaterials. J Org Chem. 2012 Dec 7;77(23):10583-95. doi: 10.1021/jo301659c. Epub 2012 Nov 15. PubMed PMID: 23121640.

Qutub Y, Reviakine I, Maxwell C, Navarro J, Landau EM, Vekilov PG. Crystallization of transmembrane proteins in cubo: mechanisms of crystal growth and defect formation. J Mol Biol. 2004 Nov 5;343(5):1243-54. PubMed PMID: 15491610.  

Landau EM, Pebay-Peyroula E, Neutze R. Structural and mechanistic insight from high resolution structures of archaeal rhodopsins. FEBS Lett. 2003 Nov 27;555(1):51-6. Review. PubMed PMID: 14630318.  

Paas Y, Cartaud J, Recouvreur M, Grailhe R, Dufresne V, Pebay-Peyroula E, Landau EM, Changeux JP. Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11309-14. Epub 2003 Sep 17. PubMed PMID: 13679581; PubMed Central PMCID: PMC208753.  

Neutze R, Pebay-Peyroula E, Edman K, Royant A, Navarro J, Landau EM. Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport. Biochim Biophys Acta. 2002 Oct 11;1565(2):144-67. Review. PubMed PMID: 12409192.  

Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.  Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5982-7. Epub 2002 Apr 23. PubMed PMID: 11972040; PubMed Central PMCID: PMC122888.  

Nollert P, Navarro J, Landau EM. Crystallization of membrane proteins in cubo. Methods Enzymol. 2002;343:183-99. Review. PubMed PMID: 11665567.  

Royant A, Nollert P, Edman K, Neutze R, Landau EM, Pebay-Peyroula E, Navarro J. X-ray structure of sensory rhodopsin II at 2.1-A resolution. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10131-6. Epub 2001 Aug 14. PubMed PMID: 11504917; PubMed Central PMCID: PMC56927.  

Pebay-Peyroula E, Neutze R, Landau EM. Lipidic cubic phase crystallization of bacteriorhodopsin and cryotrapping of intermediates: towards resolving a revolving photocycle. Biochim Biophys Acta. 2000 Aug 30;1460(1):119-32. Review. PubMed PMID: 10984595.  

Royant A, Edman K, Ursby T, Pebay-Peyroula E, Landau EM, Neutze R. Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin. Nature. 2000 Aug 10;406(6796):645-8. PubMed PMID: 10949307.  

Edman K, Nollert P, Royant A, Belrhali H, Pebay-Peyroula E, Hajdu J, Neutze R, Landau EM. High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle. Nature. 1999 Oct 21;401(6755):822-6. PubMed PMID: 10548112.  

Pebay-Peyroula E, Rummel G, Rosenbusch JP, Landau EM. X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases. Science. 1997 Sep 12;277(5332):1676-81. PubMed PMID: 9287223.  

Landau EM, Rosenbusch JP. Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14532-5. PubMed PMID: 8962086; PubMed Central PMCID: PMC26167.