Functional Bioinorganic Chemistry

Design and synthesis of modified vitamin B12 derivatives

Cobalamines catalyse important reactions in the metabolism of humans. Small amounts of vitamin B12 are essential, but fast proliferating cells such as cancer cells are strong consumers of vitamin B12. We intend to develop a new class of inhibitors of B12 dependent enzymes for cancer therapy .

Development of semi-artificial sensors and catalysts

Semi-artificial sensors and catalysts profit from the fact that a specific biological property has already been optimised to a highest degree. We intend to develop semi-artificial sensors and catalysts with novel properties. These sensors and catalysts are applied in diagnosis or could be utilized in molecular machines.