Organic Chemistry V: Enzyme Mechanisms and Natural Product Biosynthesis

Prof Dr. J. A. Robinson

Download Lecture Material

• Enzyme Chemistry part1A
  • Movie: Glycosidase in complex with Substrat, Intermediate and Product
  • Movie: Covalent glycosyl-enzyme intermediate of lysozyme
  • Movie: Neuraminidase in complex with Tamiflu
• Enzyme Chemistry part1B
  • Movie: Triosephosphate isomerase
  • Movie: Proteasome in complex with inhibitor bortezomib
  • Movie: Tosyl-a-chymotrypsin
  • Movie: Carboxypeptidase A in complex with inhibitor
  • Movie: ACE in complex with inhibitor Lisinopril
  • Movie: HIV-1 Protease complexed with inhibitor
  • Movie: Aldolase in complex with dihydroxyacetone phosphate
  • Movie: Substrate binding and catalysis mechanism of aldolase
  • Movie: Ternary complex of ADH-NAD-DMSO
  • Movie: Isosteric NAD analogues bound to ADH
  • Movie: Ternary complex of cytochrome P450 - carbon monoxide - substrate
  • Movie: Cytochrome P450 complexed with Hydroxycamphor(Catalytic product)
• Biosynthesis of Natural Products - Terpenes
  • Movie: Oxidosqualene-Lanosterol-Cyclase
• Biosynthesis of Natural Products - Polyketides
  • Movie: Mammalian Fatty Acid Synthase
• Biosynthesis of Natural Products - Shikimic acid and Alkaloids

Download Sample Exam Questions

1. July 2005
2. July 2006
3. July 2007
4. Sept 2007
5. June 2008
6. Sept 2008
7. Febr 2009
8. Febr 2010
9. Febr 2011
10. Febr 2012