Publications

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Journal Article
- 2021
  - Pullen, Sonja; Hegmans, Alexander; Hiller, Wolf G; Platzek, André; Freisinger, Eva; Lippert, Bernhard (2021). On the Heterogeneous Nature of Cisplatin‐1‐Methyluracil Complexes: Coexistence of Different Aggregation Modes and Partial Loss of NH 3 Ligands as Likely Explanation. ChemistryOpen, 10(1):28-45.
- 2020
  - Perinelli, Monica; Tegoni, Matteo; Freisinger, Eva (2020). Different Behavior of the Histidine Residue toward Cadmium and Zinc in a Cadmium-Specific Metallothionein from an Aquatic Fungus. Inorganic Chemistry, 59(23):16988-16997.
  - Salim, Alma; Chesnov, Serge; Freisinger, Eva (2020). Metallation pathway of a plant metallothionein: Cicer arietinum MT2. Journal of Inorganic Biochemistry, 210:111157.
  - Habjanič, Jelena; Mathew, Anugraha; Eberl, Leo; Freisinger, Eva (2020). Deciphering the Enigmatic Function of Pseudomonas Metallothioneins. Frontiers in Microbiology, 11:1709.
  - Habjanič, Jelena; Chesnov, Serge; Zerbe, Oliver; Freisinger, Eva (2020). Impact of naturally occurring serine/cysteine variations on the structure and function of Pseudomonas metallothioneins. Metallomics, 12(1):23-33.
- 2019
  - Steffen, Fabio D; Börner, Richard; Freisinger, Eva; Sigel, Roland K O (2019). Stick, Flick, Click: DNA-guided Fluorescent Labeling of Long RNA for Single-molecule FRET. CHIMIA International Journal for Chemistry, 73(4):257-261.
  - Freisinger, Eva; Sigel, Roland K O (2019). The Bioinorganic Periodic Table. CHIMIA International Journal for Chemistry, 73(3):185-193.
- 2018
  - Habjanič, Jelena; Zerbe, Oliver; Freisinger, Eva (2018). A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc. Metallomics, 10(10):1415-1429.
  - Cabral, Augusto C S; Jakovleska, Jovana; Deb, Aniruddha; Penner-Hahn, James E; Pecoraro, Vincent L; Freisinger, Eva (2018). Further insights into the metal ion binding abilities and the metalation pathway of a plant metallothionein from Musa acuminata. Journal of Biological Inorganic Chemistry, 23(1):91-107.
  - Freisinger, Eva; Sigel, Roland K O (2018). Celebrating Helmut Sigel. Journal of Biological Inorganic Chemistry, 23(1):1-5.
  - Zhao, Meng; Steffen, Fabio D; Börner, Richard; Schaffer, Michelle F; Sigel, Roland K O; Freisinger, Eva (2018). Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy. Nucleic Acids Research, 46(3):e13-e13.
- 2017
  - Cao, Qian; Li, Yi; Freisinger, Eva; Qin, Peter Z; Sigel, Roland K O; Mao, Zong-Wan (2017). G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs. Inorganic Chemistry Frontiers, 4(1):10-32.
- 2016
  - Tarasava, Katsiaryna; Loebus, Jens; Freisinger, Eva (2016). Localization and Spectroscopic Analysis of the Cu(I) Binding Site in Wheat Metallothionein Ec-1. International Journal of Molecular Sciences, 17(3):371.
  - Tarasava, Katsiaryna; Chesnov, Serge; Freisinger, Eva (2016). Oxidation of the N-terminal domain of the wheat metallothionein Ec-1 leads to the formation of three distinct disulfide bridges. Biopolymers, 106(3):295-308.
  - Egloff, David; Oleinich, Igor A; Zhao, Meng; König, Sebastian L B; Sigel, Roland K O; Freisinger, Eva (2016). Sequence-specific post-synthetic oligonucleotide labeling for single-molecule fluorescence applications. ACS Chemical Biology, 11(9):2558-2567.
- 2015
  - Siebel, Sabine; Dammann, Claudia; Sanz Miguel, Pablo J; Drewello, Thomas; Kampf, Gunnar; Teubner, Natascha; Bednarski, Patrick J; Freisinger, Eva; Lippert, Bernhard (2015). Analogues of Cis- and Transplatin with a Rich Solution Chemistry:cis-[PtCl2(NH3)(1-MeC-N3)] andtrans-[PtI2(NH3)(1-MeC-N3)]. Chemistry - A European Journal, 21(49):17827-17843.
  - Tarasava, Katsiaryna; Freisinger, Eva (2015). Investigating the influence of histidine residues on the metal ion binding ability of the wheat metallothionein γ-Ec-1 domain. Journal of Inorganic Biochemistry, 153:197-203.
  - Lüth, Marc Sven; Freisinger, Eva; Kampf, Gunnar; Garijo Anorbe, Marta; Griesser, Rolf; Operschall, Bert P; Sigel, Helmut; Lippert, Bernhard (2015). Connectivity patterns and rotamer states of nucleobases determine acid–base properties of metalated purine quartets. Journal of Inorganic Biochemistry, 148:93-104.
  - Egloff, David; Oleinich, Igor A; Freisinger, Eva (2015). Sequence-Specific Generation of 1,N6-Ethenoadenine and 3,N4-Ethenocytosine in Single-Stranded Unmodified DNA. ACS Chemical Biology, 10(2):547-553.
  - Freisinger, Eva; Sigel, Roland K O (2015). Preface for the JIB Special Issue for the 12th European Biological Inorganic Chemistry Conference (EuroBIC 12) in Zurich, Switzerland, August 24–28, 2014. Journal of Inorganic Biochemistry, 148:1.
- 2014
  - Tarasava, Katsiaryna; Freisinger, Eva (2014). An optimized intein-mediated protein ligation approach for the efficient cyclization of cysteine-rich proteins. Protein Engineering, Design & Selection, 27(12):481-488.
- 2013
  - Phongtongpasuk, Siriporn; Paulus, Susann; Schnabl, Joachim; Sigel, Roland K O; Spingler, Bernhard; Hannon, Michael J; Freisinger, Eva (2013). Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction. Angewandte Chemie, 125(44):11727-11730.
  - Radunsky, C; Megger, D A; Hepp, A; Kösters, J; Freisinger, Eva; Müller, J (2013). A family of hydrazone-based nucleosides for use in metal-mediated base pairs. Zeitschrift für Anorganische und Allgemeine Chemie, 639(8-9):1621-1627.
  - Wan, X; Schicht, O; Freisinger, Eva (2013). Copper(I) coordination by two plant metallothioneins. Zeitschrift für Anorganische und Allgemeine Chemie, 639(8-9):1365-1369.
  - Huber, T; Freisinger, Eva (2013). Sulfide ions as modulators of metal–thiolate cluster size in a plant metallothionein. Dalton Transactions, 42(24):8878-8889.
  - Loebus, J; Leitenmaier, B; Meissner, D; Braha, B; Krauss, G-J; Dobritzsch, D; Freisinger, Eva (2013). The major function of a metallothionein from the aquatic fungus Heliscus lugdunensis is cadmium detoxification. Journal of Inorganic Biochemistry, 127:253-260.
  - Peroza, E A; dos Santos Cabral, A; Wan, X; Freisinger, Eva (2013). Metal ion release from metallothioneins: proteolysis as an alternative to oxidation. Metallomics, 5(9):1204-1214.
  - Tarasava, K; Johannsen, S; Freisinger, Eva (2013). Solution structure of the circular γ-domain analog from the wheat metallothionein Ec-1. Molecules, 18:14414-14429.
  - Phongtongpasuk, S; Paulus, S; Schnabl, J; Sigel, Roland K O; Spingler, Bernhard; Hannon, M J; Freisinger, Eva (2013). Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction. Angewandte Chemie Internationale Edition, 52(44):11513-11516.
  - Wan, Xiaoqiong; Freisinger, Eva (2013). Incorporation of sulfide ions into the cadmium(II)-thiolate cluster of Cicer arietinum metallothionein2. Inorganic Chemistry, 52(2):785-792.
  - Freisinger, Eva; Vasak, Milan (2013). Cadmium in metallothioneins. Metal Ions in Life Sciences, 11:339-371.
- 2012
  - Seubert, K; Böhme, D; Kösters, J; Shen, W-Z; Freisinger, Eva; Müller, Jens (2012). N-Methyl-2,2’-dipicolylamine domplexes as potential models for metal-mediated base pairs. Zeitschrift für Anorganische und Allgemeine Chemie, 638:1761-1767.
  - Donghi, Daniela; Johannsen, Silke; Sigel, Roland K O; Freisinger, Eva (2012). NMR spectroscopy in bioinorganic chemistry. CHIMIA International Journal for Chemistry, 66(10):791-797.
- 2011
  - Galstyan, A; Sanz Miguel, P J; Wolf, J; Freisinger, Eva; Lippert, B (2011). Discrete Molecular Squares {[(en)M(CN)]4}4+ Derived from [(en)M(CN)2] (M = PtII, PdII). European Journal of Inorganic Chemistry, 2011(10):1649-1656.
  - Freisinger, Eva (2011). Structural features specific to plant metallothioneins. Journal of Biological Inorganic Chemistry, 16(7):1035-1045.
  - Galstyan, A; Shen, W Z; Freisinger, Eva; Alkam, H; Hiller, W; Sanz Miguel, P J; Schürmann, M; Lippert, B (2011). Supramolecular Isomerism of 2,2′-Bipyrazine Complexes with cis-(NH3)2PtII: Ligand Rotational State and Sequential Orientation Determine the 3D Shape of Metallacycles. Chemistry - A European Journal, 17(38):10771-10780.
  - Loebus, J; Peroza, E A; Blüthgen, N; Fox, T; Meyer-Klaucke, W; Zerbe, O; Freisinger, Eva (2011). Protein and metal cluster structure of the wheat metallothionein domain gamma-Ec-1: the second part of the puzzle. Journal of Biological Inorganic Chemistry, 16(5):683-694.
- 2010
  - Freisinger, Eva (2010). The metal-thiolate clusters of plant metallothioneins. CHIMIA International Journal for Chemistry, 64(4):217-224.
- 2009
  - Peroza, E; Schmucki, Roland; Güntert, P; Freisinger, Eva; Zerbe, Oliver (2009). The βE-domain of wheat Ec-1 metallothionein: a metal-binding domain with a distinctive structure. Journal of Molecular Biology, 387(1):207-218.
  - Wan, X; Freisinger, Eva (2009). The plant metallothionein 2 from Cicer arietinum forms a single metal-thiolate cluster. Metallomics, 1(6):489-500.
  - Said, M; Murtaza, G; Freisinger, Eva; Anwar, S; Rauf, A (2009). (Z)-2-Phenyl-3-pivaloyl-1,1-dipropylguanidine. Acta Crystallographica. Section E, Structure Reports Online, 65(9):o2073-o2074.
  - Peroza, E A; Al Kaabi, A; Meyer-Klaucke, W; Wellenreuther, G; Freisinger, Eva (2009). The two distinctive metal ion binding domains of the wheat metallothionein Ec-1. Journal of Inorganic Biochemistry, 103(3):342-353.
  - Schicht, O; Freisinger, Eva (2009). Spectroscopic characterization of Cicer arietinum metallothionein 1. Inorganica Chimica Acta, 362(3):714-724.
- 2008
  - Freisinger, Eva (2008). Plant MTs-long neglected members of the metallothionein superfamily. Dalton Transactions, (47):6663-6675.
  - Shen, W Z; Schnebeck, R D; Freisinger, Eva; Lippert, B (2008). On the interrelationship of µ-OH bridged dimers, trimers, and tetramers of (en)PtII and their Ag+ adducts. Dalton Transactions, (30):4044-4049.
  - Müller, J; Polonius, F A; Freisinger, Eva; Bardají, E G (2008). X-ray crystallographic study of several 2′-deoxy-β-d-ribonucleosides with 1-deazapurine-derived aglycones. Carbohydrate Research, 343(2):397-403.
  - Peroza, E A; Freisinger, Eva (2008). Tris is a non-innocent buffer during intein-mediated protein cleavage. Protein Expression and Purification, 57(2):217-225.
  - Freisinger, Eva; Griesser, R; Lippert, B; Moreno-Luque, C F; Niclós-Gutiérrez, J; Ochocki, J; Operschall, B P; Sigel, H (2008). Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa). Chemistry - A European Journal, 14(32):10036-10046.
- 2007
  - Müller, Jens; Freisinger, Eva; Lax, Patrick; Megger, Dominik A; Polonius, Fabian-Alexander (2007). Interaction of Pt(II) and Pd(II) complexes of terpyridine with 1-methylazoles: A combined experimental and density functional study. Inorganica Chimica Acta, 360(1):255-263.
  - Gallo, S; Freisinger, Eva; Sigel, Roland K O (2007). Towards the synthesis of light-stable coenzyme B12 analogs. Inorganica Chimica Acta, 360(1):360-368.

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