High-Throughput Experimentation Laboratory
Welcome to the High-Throughput Experimentation Lab of the Department of Chemistry at UZH
BREAKING NEWS:
The equipment in the HTEL is now complete and is geared up for full operation!
Over summer, the centrepiece of the HTEL, the SWING XL robotic platform by Chemspeed Technologies, was completed by the installation of another syringe-based liquid handling tool and a magnetic tumble stirrer module.
Additionally, later in September the Glovebox with the Chemspeed robot was attached to another mBraun glovebox for preparation and storage, which is attached to a solvent purification system. With this last piece of the big puzzle delivered, the equipment of the HTEL is essentially complete. With a few smaller developments and refinements still to be done on the side, the HTEL is now ready for full operation and the first pilot project on the chemistry platform is already on the way.
The infrastructure in the HTEL now features a variety of tools to accelerate and facilitate chemical research in many different ways. Capabilities involve automated solid and liquid dispensing, parallel reactions under inert atmosphere, photochemical reactions using different wavelengths, reactions using reactive gases under pressure, and parallelised workflows for dilution, filtration, extraction, evaporation. The system is currently still in testing and preparation, so stay tuned!
This is complemented by support of workflows in biochemistry, medicinal chemistry or sample preparations. which are incompatible with glovebox conditions by employing pipetting robots by Opentrons (OT2, Flex). Due to the low-level access barrier and available user training, these machines
have already seen various applications ranging from reaction optimisation to luminescence assays.The Opentrons robots are accompanied by setups for SPE, centrifugation, evaporation, incubation and multimode plate reading.
Find out more details on our equipment here.
Do you want to explore new avenues by automated equipment and have ideas that you want to try leveraging the new HTEL infrastructure? Or do you want to run a rapid UHPLC/MS analysis of samples in a 96 or 384-WP? Or are you simply curious about the HTEL project? Don’t hesitate to reach out to us!
Interested in our new minor study programme “Lab Automation and Chemical Data Science”? Find more details here.
For any information on the minor or the UZH HTEL, contact:
Dr. Johannes Schörgenhumer
Senior Scientist - HTE Lab
Room: Y38-G-10
Phone: +41 44 63 54694
Mail: Johannes Schörgenhumer