Haibo Wang

Haibo Wang, Dr.

Phone: +41 44 63 54642

Room number: Y34-F-94

haibo.wang@chem.uzh.ch

Education


2021.01 – present

Postdoctoral fellow, Department of Chemistry, University of Zurich     

Research area: G-quadruplex solution structure, G4-protein interaction

Advisor: Prof. Roland K. O. Sigel

2018.04 – 2020.12

Postdoctoral fellow, Department of Chemistry, The University of Hong Kong                                                                       

Research area: medicinal structure biology

Advisor: Prof. Hongzhe Sun

2013.09 – 2018.03

Ph.D. in Chemical Biology, Department of Chemistry, The University of Hong Kong  

Thesis title: Uncovering the silver proteome enables in-depth deciphering its molecular mechanism.

Advisor: Prof. Hongzhe Sun

2009.09 – 2013.06

B.Sc. in Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University

Thesis title: Synthesis and characterization of novel phosphate esterase mimics containing β-cyclodextrins

Advisor: Prof. Zongwan Mao

Professional Membership


2019.11 - present

Fellow member, HK Bio-Med Innotech Association (HKBMIA), Hong Kong

2019.11 - present

Fellow member, Chinese Chemical Society (CCS), China

2017.12 - present

Fellow member, Society of Biological Inorganic Chemistry (SBIC)

 

Publication List

 

  1. Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun*, Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance. Nature Communications, 2021. 12,3331.

  2. Xiaohan Xu,‡ Haibo Wang,‡ Hongyan Li, Hongzhe Sun*, Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of darinaparsin®: insights into novel therapeutic strategy. CCS Chemistry. 2021, 3, 1089-1100. (co-first author)

  3. Haibo Wang*, Xinming Yang, Minji Wang, Xiaohan Xu, Menglong Hu, Aixin Yan, Quan Hao, Hongyan Li and Hongzhe Sun*, Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem. Sci., 2020, 11,11714. (Co-corresponding author, back cover)

  4. Haibo Wang, Ying Zhou, Xiaohan Xu, Hongyan Li and Hongzhe Sun* Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development. Curr. Opin. Chem. Biol., 2020. 55, 171-179.

  5. Haibo Wang, Minji Wang, Xinming Yang, Xiaohan Xu, Quan Hao, Aixin Yan, Menglong Hu, Hongyan Li, Hongzhe Sun*, Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli. Chem. Sci., 2019, 10, 7193-7199.

  6. Haibo Wang, Aixin Yan, Zhigang Liu, Xinming Yang, Zeling Xu, Yuchuan Wang, Runming Wang, Mohamad Koohi-Moghadam, Ligang Hu, Wei Xia, Huiru Tang, Yulan Wang, Hongyan Li, Hongzhe Sun*, Deciphering molecular mechanism of silver enables enhancing its antimicrobial efficacy in E. coli. PLoS. Biol., 2019, 17(6): e3000292.

  7. Yuchuan Wang‡, Bingjie Han‡, Yanxuan Xie‡, Haibo Wang‡, Runming Wang, Wei Xia, Hongyan Li, Hongzhe Sun*, Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosa. Chem. Sci., 2019. 10, 6099-6106. (co-first author)

  8. Xiaohan Xu‡, Haibo Wang‡, Hongyan Li, Xuqiao Hu, Yu Zhang, Xinyuan Guan, Patrick-Henry Toy, Hongzhe Sun*, S-dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukaemia cells. Chem. Commun., 2019, 55, 13120-13123. (co-first author)

  9. Hongzhe Sun†*, Qi Zhang†, Runming Wang†*, Haibo Wang, Yuen-Ting Wong, Minji Wang, Quan Hao, Aixin Yan, Richard Yi-Tsun Kao, Pak-Leung Ho, Hongyan Li. Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nature Communications, 2020. 11, 5263.

  10. Mohamad Koohi-Moghadam, Haibo Wang, Yuchuan Wang, Xinming Yang, Hongyan Li, Junwen Wang*and Hongzhe Sun* Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach. Nature Machine Intelligence, 2019, 1, 561–567.

  11. Xiaohan Xu, Haibo Wang, Hongyan Li, Hongzhe Sun*, Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS). Chem. Lett., 2020. 49, 697–704.

  12. Zeling Xu, Pengchao Wang, Haibo Wang, Zuo Hang Yu, Ho Yu Au-Yeung, Tasuku Hirayama, Hongzhe Sun, Aixin Yan*, Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli. J. Biol. Chem., 2019. 294, 16978–16991.

  13. Ying Zhou, Haibo Wang, Eric Tse, Hongyan Li, Hongzhe Sun*, Cell cycle-dependent uptake and cytotoxicity of arsenic-based drugs in single leukemia cells. Anal. Chem., 2018, 90, 10465-10471.

  14. Hu Xuqiao, Hongyan Li, Tiffany Ka-Yan Ip, Yam-Fung Cheung, Mohamad Koohi-Moghadam, Haibo Wang, Xinming Yang, Daniel Tritton, Yuchuan Wang, Yi Wang, Runming Wang, Kwan-Ming Ng, Hua Naranmandura, Eric Tse and Hongzhe Sun*, Arsenic trioxide targets Hsp60, triggering degradation of p53 and surviving. Chem. Sci., 2021, doi.org/10.1039/D1SC03119H.

  15. Bingjie Han, Zhen Zhang, Yanxuan Xie, Wei Xia, Xuqiao Hu, Haibo Wang, Yulan Wang, Hongyan Li, Yuchuan Wang*and Hongzhe Sun*, Multi-omics and temporal dynamics profiling reveals disruption of central metabolism in Helicobacter pylori by bismuth drug. Chem. Sci., 2018, 9, 7488-7497.

  16. Yuchuan Wang, Haibo Wang, Hongyan Li and Hongzhe Sun*, Chapter 9, Application of metallomics and metalloproteomics for understanding the molecular mechanisms of action of metal-based drugs, Essential and Non-essential Metals, Springer, Page 199-222, 2017, edited by Dr. Anuradha Mudipalli & Judith T. Zelikoff. (Book chapter)

  17. Haibo Wang, Yuchuan Wang and Hongzhe Sun*, Chapter 3, Metallomics and bioinorganic chemistry, Metallomics, China Science Press, Page 38-57, 2016, edited by Dr Yufeng Li. (Book chapter)

  18. Yuchuan Wang, Haibo Wang, Hongyan Li and Hongzhe Sun*, Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugs. Dalton. Trans., 2015, 44, 437-447.

  19. Yuen-Yan Chang, Yau-Tsz Lai, Tianfan Cheng, Haibo Wang, Ya Yang and Hongzhe Sun*, Selective interaction of Hpn-like protein with nickel, zinc, and bismuth in vitro and in cells by FRET. J. Inorg. Biochem., 2015, 142, 8-14.

  20. Meng Zhao, Hai-Bo Wang, Liang-Nian Ji and Zong-Wan Mao*, Insights into metalloenzyme microenvironments: biomimetic metal complexes with a functional second coordination sphere. Chem. Soc. Rev., 2013, 42, 8360-8375.

  21. Hai-Bo Wang, Meng Zhao, Liang-Nian Ji and Zong-Wan Mao*, Metalloenzyme Mimics with Non-Covalent Interactions. Prog. Chem., 2013, 25, 577-588.

Honors and Awards


Aug. 2017

Best Young Scientist Award (3/150, 500 €, ISM6, Vienna, Austria)

Aug. 2017

Outstanding Teaching Assistant Awards

Dec. 2016

Travel award (400 $, AsBIC8, Auckland, New Zealand)

Jul. 2015

Best presentation award & travel award (3/250, 400 $, ICBIC17, Beijing, China)

Dec. 2014

Best poster award & travel award (3/150, 500$, AsBIC7, Gold Coast, Australia)

Sep. 2013 -
Aug. 2017

Hong Kong PhD Fellowship (HKPFS) (1/100, 2013-2017, four-year fellowship)

Jun. 2012

Sun Yat-Sen University 2010-2012 Outstanding Communist Party Member (1/370)

Sep. 2012

National scholarship (2/370); the first prize scholarship (top 1%)

Sep. 2011

The first prize scholarship (top 1%); Zeng Xianzi Excellent Student Scholarship

Sep. 2010

The first prize scholarship (top 1%)

Jul. 2011

Third Prize in Challenge Cup Competition (Chemistry Experiment Competition)

Nov. 2010

The Championship in the Campus Relay Race (team race)

Conference and Symposium

 

Organization members

  1. Crouch ASI Metals in Biology and Medicine. The University of Hong Kong, Hong Kong, Dec. 11-13, 2020. (Funding acquisition and organizing secretary)

  2. Metals in Life Processes. The University of Hong Kong, Hong Kong, Dec. 5, 2018. (Organizing secretary)

  3. Symposium on Combatting Antimicrobial Resistance. The University of Hong Kong, Hong Kong, Apr. 13, 2016. (Organizing helper)

  4. 5th Asian Conference on Coordination Chemistry (ACCC5), Hong Kong, Jul. 12-16, 2015. (Organizing helper)

  5. The 12th International Symposium on Applied Bioinorganic Chemistry, Guangzhou, China, Dec. 3-6, 2013. (Organizing secretary)

Oral presentations

  1. Digital Bioinorganic Chemistry Symposium, University of Zurich, Zurich, Switzerland, Dec. 9-10, 2019.

  2. 6th National Conference on Biophysical Chemistry (NCBPC-6), Hengyang, Hunan Province, China, Oct. 23-26, 2019.

  3. 19th International Conference on Biological Inorganic Chemistry (ICBIC-19), Interlaken, Switzerland, Aug. 11-16, 2019.

  4. 6th International Symposium on Metallomics (ISM6), Vienna, Austria, Aug. 14-17, 2017. (Best Young Scientist award)

  5. 17th International Conference on Biological Inorganic Chemistry (ICBIC17), Beijing, China, Jul. 20-25, 2015. (Best presentation award & travel award)

  6. 7th Asian Biological Inorganic Chemistry Conference (AsBIC7), Gold Coast, Australia, Dec. 1-5, 2014. (Poster and oral presentation, travel award & best poster award)

Poster presentations

  1. 11th Chinese National Conference on Chemical Biology (CNCCB11), Guangzhou, China, Nov. 18-22, 2019.

  2. 8th Asian Biological Inorganic Chemistry Conference (AsBIC8), Auckland, New Zealand, Dec. 4-9, 2016. (Travel award)

  3. 5th International Symposium on Metallomics (ISM5), Beijing, China, Sept. 9-12, 2015.

  4. 21st, 22nd, 23rd and 24th Symposium on Chemistry Postgraduate Research in Hong Kong, 2014, 2015, 2016, 2017.

  5. The 6th Asian Biological Inorganic Chemistry Conference (AsBIC6), HongKong, China, Nov. 5-8, 2012.

Attendance

  1. NSFC-BHKAEC Joint Symposium on Chemistry for New Frontiers, The University of Hong Kong, Hong Kong, Jul. 28-31, 2019.

  2. HKEX, 2nd Biotech Summit, Hong Kong, May 28-30, 2019.

  3. International Symposium on Antimicrobial Resistance in the Environment (ISARE 2017), Shenzhen, China, Nov. 30-Dec. 3, 2017.

  4. Swiss Chemical Society (SCS) Fall Meeting, Bern, Switzerland, Aug. 21-22, 2017.

  5. International Conference on Global Food Safety and Antimicrobial Resistance (GFSAR 2016), Shenzhen, China, Nov. 14-16, 2016.