Oliver Zerbe's Publications


  • O. Zerbe, C. Baumann, M. Schuster, K. Oi, K. Moehle, E. Michel, Peptides in BioNMR Research, Chimia, 75, 505-507.
  • S. Cucuzza, P. Güntert, A. Plückthun, O. Zerbe, An automated iterative approach for protein structure refinement using pseudocontact shifts, J. Biomol. NMR, https://doi.org/10.1007/s10858-021-00376-8.



  • J. Habjanic, S. Chesnov, O. Zerbe, Eva Freisinger: Impact of naturally occurring serine/cysteine variations on the structure and function of Pseudomonas metallothioneins, Metallomics, 12, 23-33.
  • L. Kooijman, P. Ansorge, M. Schuster, C. Baumann, F. Löhr, S. Jurt, P. Güntert and O. Zerbe,  NMR Backbone and methyl assignment of bacteriorhodopsin incorporated into nanodiscs, J. Biomol. NMR, 74, 45-60.
  • R. Dallinger*,   O. Zerbe*,   C. Baumann,   B. Egger,   M. Capdevila,   O. Palacios,   R. Albalat,   S. Calatayud,   P. Ladurner,   B. Schlick-Steiner,   F. Steiner,   V. Pedrini-Martha, R. Lackner,   H. H. Lindner,   M. Dvorak,   M. Niederwanger,   R. Schnegg  and  S. Atrian: Variable environmental cadmium levels through the last 445 million years have triggered convergent evolution of Cd-selective snail metallothioneins and their metal-specific diversification, Metallomics,12, 702.
  • M. Schuster, M. DeLuigi, M. Pantic, S. Vacca, C. Baumann, M. D. Scott, A. Plückthun and O. Zerbe: Optimizing the a1B-Adrenergic Receptor for Solution NMR Studies, BBA Biomembranes, 1862, 183354.
  • L. Kooijman, M. Schuster, C. Baumann, S. Jurt, F. Löhr, B. Fürtig, P. Güntert and O. Zerbe,  Dynamics of Bacteriorhodopsin in the Dark-Adapted  State from Solution NMR, Angew. Chem. Int. Ed., 59, 20965-72.



  • E. Michel, A. Plückthun, O. Zerbe: Peptide binding affinity redistributes preassembled repeat protein fragments, Biol. Chem., 400, 393-404.
  • L. S. Manni, S. Assenza, M. Duss, J. J. Vallooran, F. Juranyi, S. Jurt, O. Zerbe, E. M. Landau, R. Mezzenga: Soft biomimetic nanoconfinement promotes amorphous water over ice, Nat. Nanotechnol. 14, 609-615.
  • A. Beil, S. Jurt, R. Walser, T. Schönhut, P. Güntert, Òscar Palacios , S. Atrian, Mercè Capdevila, R. Dallinger, O. Zerbe: The Solution Structure and Dynamics of Cd-Metallothionein from Helix pomatia Reveal Optimization for Binding Cd over Zn., Biochemistry, 58, 470-4581.
  • M. Dvorak, R. Schnegg, W. Salvenmoser, Ò. Palacios, H. Lindner, O. Zerbe, A. Hansel, M. Leiminger, G. Steiner, R. Dallinger, R. Lackner, Distinct pathways for zinc metabolism in the terrestrial slug, Arion vulgaris, Sci Rep. 9,20089.



  • E. Michel, A. Plückthun, O. Zerbe: Peptide-Guided Assembly of Repeat Protein Fragments, Angew. Chem. Int. Ed., 57, 4576-4579.
  •  J. Marino R. Walser, M. Poms and O. Zerbe: Understanding GPCR Recognition and Folding from NMR Studies of Fragments, RSC Advances,  8, 9858 - 9870.
  • L. Simonelli, M. Pedotti, M. Bardelli, S. Jurt, O. Zerbe and L. Varani, Mapping Antibody Epitopes by Solution NMR Spectroscopy: Practical Considerations. Meth. Mol. Biol., 1785 (2018), 29-51.
  • J. Habjanic, O. Zerbe, E. Freisinger:A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc, Metallomics, 10, 1415-1429.
  • S. U.Vetterli, K. Zerbe, M. Müller, M. Urfer, M. Mondal, S.-Y. Wang, K. Moehle, O. Zerbe, A. Vitale, G. Pessi, L. Eberl, B. Wollscheid and J. A. Robinson , Thanatin Targets the Inter-Membrane Protein Bridge Required for Lipopolysaccharide Transport in Escherichia coli , Science Advances, 4 , eaau2634.



  • C. Baumann, A. Beil. S. Jurt, M Niederwanger, O. Palacios, M. Capdevila, S. Atrian, R. Dallinger, O. Zerbe: Structural adaptation of a protein to increased metal stress: NMR structure of a marine snail metallothionein with an additional domain, Angew. Chem.Int. Ed., 56, 4617-4622 (hot paper).
  • M. Niederwanger , S. Calatayud, O. Zerbe, S. Atrian, R. Albalat, M. Capdevila, Ò. Palacios,  R. Dallinger: Lacking Metal Specificity of the Protein and Missing Gene Upregulation Suggest Metal Sequestration by Exchange Instead of through Selective Binding, Int. J. Mol. Sci. 18 , 1457.
  • Ò. Palacios , E. Jiménez-Martí , M. Niederwanger, S. Gil-Moreno, O. Zerbe, S. Atrian, R. Dallinger, M. Capdevila: Analysis of Metal-Binding Features of the Wild Type and Two Domain-Truncated Mutant Variants of Littorina littorea Metallothionein Reveals Its Cd-Specific Character, Int. J. Mol. Sci. 18, 1452.
  • J. Wang, M. Bardelli, D. Espinosa, M Pedotti, T. Ng, S. Bianchi, L. Simonelli, E. Lim1,2, M. Foglierini, F. Vanzetta, S. Jaconi, M. Beltramello, E. Cameroni, G. Fibriansah,  J. Shi, T. Barca, I. Pagani, A. Rubio, V. Broccoli, E. Vicenzi, V. Graham, S. Pullan, S. Dowall, R. Hewson, S. Jurt, O. Zerbe, K. Stettler, A. Lanzavecchia, F. Sallusto, A. Cavalli, E. Harris, S. Lok, L. Varani, D. Corti: A human bi-specific antibody against Zika virus with high therapeutic potential, Cell, 171 , 229-241.



  • S. Gil-Moreno, E. Jiménez-Martí, Ò. Palacios, O. Zerbe, R. Dallinger, M. Capdevila and S. Atrian: Does Variation of the Inter-Domain Linker Sequence Modulate the Metal Binding Behaviour of Helix pomatia Cd-Metallothionein? Int. J. Mol. Sci. 17, 6.
  • K. Moehle, H. Kocherla, B. Bacsa, S. Jurt, K. Zerbe, J. A. Robinson, O.Zerbe: Solution structure and dynamics of LptE from Pseudomonas aeruginosa, Biochemistry, 55, 2936-2943.
  • C. Reichen, C. Forzani, A. Honegger, S.J. Fleishman, T. Zhou, F. Parmeggiani, P. Ernst,  P.R. E. Mittl, C. Madhurantakam,  C. Ewald, O. Zerbe, D. Baker, A. Caflisch and A. Plückthun: Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition, J. Mol. Biol, 428,4467-4489.
  • F. Fumagalli , J. Noack , T. Bergmann , E. Cebollero , G. Brambilla Pisoni , E. Fasana , I. Fregno , C. Galli , M. Loi , T. Soldà , R. D'Antuono , A. Raimondi , M. Jung , A. Melnyk , S. Schorr , A. Schreiber , L. Simonelli , L. Varani , C. Wilson-Zbinden , O. Zerbe , K. Hofmann , M. Peter , M. Quadroni , R Zimmermann, M. Molinar: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery, Nature Cell Biol., 18,1173-1185.
  • M. Poms, P. Ansorge, L. Martinez-Gil, S. Jurt, D. Gottstein, K. Caroccia, L. Cohen, P. Güntert, I. Mingarro, F. Naider, O.Zerbe: NMR Investigation of Structures of GPCR Folding Intermediates, J. Biol. Chem., 291, 27170–2718.



  • J. Marino, N. Bordag, S. Keller, O. Zerbe: Mistic’s membrane association and its assistance in overexpression of a human GPCR are independent processes, Prot. Sci., 24, 38-48.
  • J. Marino, M. Hohl, M. Seeger, O. Zerbe, E. Gertsma: Dicistronic mRNAs to enhance membrane protein  overexpression, J. Mol. Biol., 427, 943-954.
  • K. Caroccia, L. Cohen, B. Arshava, M. Poms, O. Zerbe, J. Becker, F. Naider: Structural Characterization of Triple Transmembrane Domain Containing Fragments of a Yeast G Protein-Coupled Receptor in an Organic:Aqueous Environment by Solution-State NMR Spectroscopy, J. Pept. Sci, 21, 212-221.
  • C. Ewald, M.T. Christen, R. Watson, M. Mihajlovic, T. Zhou, A. Honegger, A. Plückthun, A. Caflisch, O. Zerbe: A Combined NMR and Computational Approach to Investigate Peptide Binding to a Designed Armadillo Repeat Protein, J. Mol. Biol., 427,1916-1933.
  • S. Jurt, O. Zerbe: NMR in Chemistry and the Life Sciences,- New Challenges and Opportunities, GIT Laboratory Jounal, 19, 8-10.



  • C. T. Van, T. Zdobinsky, G. Seebohm,D. Nennstiel, O. Zerbe, J.Scherkenbeck: Structural prerequisites for receptor binding of helicokinin I, a diuretic insect neuropeptide from Helicoverpa zea, Eur. J. Chem. Org. Chem., 13, 2714-2725.
  • P. Gutte, S. Jurt, M. Grütter, O. Zerbe : The solution NMR structure of the NLRC5 caspase recruitment domain (CARD) reveals unusual structural features, Biochemistry, 53, 3106-3117.
  • R. Watson, M. Christen, C. Ewald, F. Bumback, C. Reichen, M. Mihajlovic, E. Schmidt, P. Güntert, A. Plückthun, A. Caflisch, O. Zerbe (2014): Spontaneous Self-Assembly of Engineered Armadillo Repeat Protein Fragments into a Folded Structure, Structure, 22, 985-995.



  • M. Steger, O. Murina, D. Hühn, L. P. Ferretti, R. Walser, K. Hänggi, L. Lafranchi, C. Neugebauer, S. Paliwal, P. Janscak, B. Gerrits, G. Del Sal, O. Zerbe, A. A. Sartori: Prolyl Isomerase PIN1 Regulates DNA Double-Strand Break Repair by Counteracting DNA End Resection, Mol. Cell, 50, 333-343.
  • B. Buchli, S.A. Waldauer, R. Walser, M. Donten, R. Pfister, S. Steiner, A. Caflisch, O. Zerbe, P. Hamm : Kinetic Response of a Photo-Perturbed Allosteric Protein, Proc. Natl. Acad. Sci. USA, 110, 11725-11730.
  • Oliver Zerbe, Simon Jurt: Applied NMR Spectroscopy for Chemists and Life Scientists, 1st Edition, Wiley-VCH, Weinheim 2013.



  • O. Zerbe: First solution structures of 7–transmembrane helical proteins, Angew. Chem. Int. Ed., 51, 860-861.
  • H. Kocherla, J. Marino, X. Shao, J. Graf, C. Zou, O. Zerbe: Biosynthesis and spectroscopic characterization of 2-TM fragments encompassing the sequence of a human GPCR, the Y4 receptor, ChemBioChem, 13, 818 – 828.
  • S.L. Pedersen, V.K. Bhatia,  S. Jurt, J.F. Paulsson, M.H. Pedersen, R. Jorgensen, B. Holst, D. Stamou, N. Vrang, O. Zerbe and K.J. Jensen, Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36, J. Pept. Sci., 18, 579-587.
  • X. Shao, C. Zou, F. Naider, O. Zerbe: Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G protein coupled receptors, Biophys. J., 103, 817-826.
  • P. Alfarano, G. Varadamsetty, C. Ewald, F. Parmeggiani, R. Pellarin, O. Zerbe, A. Plückthun, A. Caflisch: Optimization of designed armadillo repeat proteins by molecular dynamics simulations and NMR spectroscopy, Prot. Sci., 21, 1298-1314.
  • J. Marino, E. Geertsma, O. Zerbe: Topogenesis of heterologously expressed fragments of the human Y4 GPCR, BBA Biomembranes, 1818, 3055-3063.
  • R. Walser, J.H. Kleinschmidt, A. Skerra and O. Zerbe, beta-Barrel scaffolds for grafting of extracellular loops of GPCRs, Biol. Chem., 393,1341-1355.
  • R. Walser and O. Zerbe: Approaches towards structures of Y receptors, examples of human G-protein coupled receptors, by solution NMR, Chimia, 66, 781-786.
  • S. Jurt, O. Zerbe: A study on the influence of fast amide exchange on the accuracy of 15N relaxation rate constants, J. Biomol. NMR, 54, 389-400.



  • J. Löbus, E.A. Peroza , N. Blüthgen,  T. Fox,  W. Meyer-Klaucke,  O. Zerbe,  E. Freisinger: Protein and metal cluster structure of the wheat metallothionein domain γ-E(c)-1: the second part of the puzzle, J. Biol. Inorg. Chem., 16, 683-694.
  • R. Walser, J.H. Kleinschmidt and O. Zerbe: A GPCR mini-receptor mimicking the extracellular loops of the human Y1 receptor, ChemBioChem, 12, 1690-1693.
  • L.S. Cohen, B. Arshava, A. Neumoin, J.M. Becker, P. Güntert, O. Zerbe and F. Naider (2011), Comparative NMR Analysis of an 80-Residue G Protein-Coupled Receptor Fragment in Two Membrane Mimetic Environments, BBA Biomembranes, 1808, 2674-2684.
  •  K. E. Caroccia, R. Estephan, L. S. Cohen, B. Arshava, M. Hauser, O. Zerbe, J.M. Becker and F. Naider,  Expression and biophysical analysis of a triple-transmembrane domain-containing fragment from a yeast G protein-coupled receptor, Biopolymers Pept. Sci., 96, 957-971.



  • O. Zerbe, Die molekularen Mechanismen des Sehens, book chapter in "Sinne", Ingrid Tomkowiak (Editor), Chronos Verlag 2010.
  • N. Keller, M.G. Grütter, O. Zerbe: Studies of the Molecular Mechanism of caspase-8 Activation by Solution NMR, Cell Death Differ., 17, 710-71.
  • E. Ortner, V. Schroeder, R. Walser, O. Zerbe, H.-P. Kohler , Sensitive and selective detection of free FXIII activation peptide: A potential marker of acute thrombotic events, Blood, 115, 5089-5096.
  • S. Wetzel, C. Ewald, G. Settanni, S. Jurt, A. Plückthun, O..Zerbe, Residue-resolved stability of full-consensus ankyrin repeat proteins probed by NMR, J. Mol. Biol., 402, 241-258



  • C. Zou, S. Kumaran, R. Walser, O. Zerbe, Properties of the N-terminal domains from Y receptors probed by NMR spectroscopy, J. Pept. Sci., 15, 184-191.
  • E. Peroza, R. Schmukli, P. Güntert, E. Freisinger, O. Zerbe, The βE-domain of wheat Ec-1metallothionein: A metal-binding domain with a distinctive structure, J. Mol. Biol., 387, 207-218.
  • N. Keller, J. Mares, O. Zerbe, M. Grütter, Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation, Structure,17, 438-448.
  • J. Mares, S. Kumaran, M. Gobbo, O. Zerbe, Interactions of lipopolysaccharide and polymyxin studied by NMR spectroscopy, J. Biol. Chem., 284, 11498-11506.
  • A. Neumoin, L. S. Cohen, B. Arshava, S. Tantry, J. Becker, O. Zerbe, F. Naider , Structure of a Double Transmembrane Fragment of a G Protein-Coupled Receptor in Micelles, Biophys. J., 96,3187-3196.
  • T. Zdobinsky, J. Scherkenbeck, O. Zerbe, Horst Antonicek, Structures of Micelle-Bound Selected Insect Neuropeptides and Analogues: Implications for Receptor Selection, ChemBioChem, 10, 2644-2653.
  • R. Maag, B.H. Northrop, A. Butterfield, A. Linden, O. Zerbe, Y.M. Lee, K-W. Chi, P.J. Stang, J.S. Siegel (2009), Synthesis and X-ray structural analysis of platinum and ethynyl-platinum corranulenes: spramolecular tectons, Org. Biolmol. Chem., 7, 4881–4885.



  • F. Parmeggiani, R. Pellarin, A. P. Larsen, G. Varadamshetty, O. Zerbe, A. Caflisch, A. Plückthun: Designed Armadillo Repeat Proteins as General Peptide Binding Scaffolds, J. Mol. Biol., 376,1282-1304.
  • L. S. Cohen, B. Arshava, R. Estephan, J. Englander, H. Kim, M. Hauser, O. Zerbe, M. Ceruso, J. M. Becker, F. Naider: Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor, Biopolymers Pept. Sci., 90, 117-130.
  • C. Zou, S. Kumaran, S. Markovic, R. Walser, O. Zerbe: Studies of the structure of the N-terminal domain from the Y4 receptor, a G-protein coupled receptor, and its interaction with hormones from the NPY family, ChemBioChem, 9, 2276-2284 (cover page).

  • C. Zou, F. Naider, O. Zerbe: Biosynthesis and NMR-Studies of a Double Transmembrane Domain from the Y4 Receptor, a Human GPCR, J. Biomol. NMR, 42, 257 - 269.
  • E.H.G. Backus, P.H. Nguyen, V. Botan, A. Moretto, M. Crisma, C. Toniolo, O. Zerbe, G. Stock, P. Hamm: Structural flexibility of a helical peptide regulates heat transport properties, J. Phys. Chem., 112, 15487–15492



  • M.C. Erat, O. Zerbe, T. Fox, R.K.O. Sigel: Solution Structure of Domain 6 from a Self-Splicing Group II Intron Ribozyme: A Mg2+ Binding Site is Located Close to the Stacked Branch Adenosine, ChemBioChem, 8, 306-314.
  • Neumoin, A., Arshava, B., Becker, J., Zerbe, O.*, Naider, F.*: NMR studies in DPC of a fragment containing the seventh transmembrane helix of a GPCR from Saccharomyces cerevisiae, Biophys. J., 93, 467-482.
  • Neumoin, A., Mares, J., Lerch-Bader, M., Bader, R., Zerbe, O.:Probing the Formation of Stable Tertiary Structure in a Model Miniprotein at Atomic Resolution: Determinants of Stability of a Helical Hairpin, J. Am. Chem. Soc., 129, 8811-8817.



  • R. Fasan, R.L.A. Dias, K. Möhle, O. Zerbe, D. Obrecht, P.E.R. Mittl, M.G. Grütter, J.A. Robinson: Structure-Activity Studies in a Family of beta-Haipin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction, ChemBioChem, 7, 515-526.
  • S. Jurt, A. Aemissegger, P. Güntert, O. Zerbe*, D. Hilvert*: A Photoswitchable Miniprotein Based on the Sequence of Avian Pancreatic Polypeptide, Angew. Chem. Int. Ed., 45, 6297-6300.
  • J. Mares, J.U. Müller, A. Skirgailiene, A. Neumoin, C.A. Bewley, R.R. Schmidt and O. Zerbe: A model for cell-surface exposed carbohydrate moieties suitable for structural studies by NMR, ChemBioChem,7, 1764-1773.
  • O. Zerbe, A. Neumoin, J. Mares, R. Walser and C. Zou: Recognition of Neurohormones of the NPY Family by their Receptors, J. Recept. Signal Tr. Res., 26, 487-504



  • N.Walch, T. Kühn, D. Moskau, O. Zerbe (2005) Strategies and Tools for Structure Determination of Natural Products Using Modern Methods of NMR Spectroscopy, Chemistry and Biodiversity, 2, 147-177.
  • M. Lerch, H. Kammimori, G. Folkers, M. Aguilar, A.G. Beck-Sickinger, O. Zerbe (2005) Strongly Altered Receptor Binding Properties in PP and NPY Chimera are Accompanied by Changes in Structure and Membrane Binding, Biochemistry, 44, 9255 - 9264.
  • R. Bader, O. Zerbe (2005) Are Hormones from the Neuropeptide Y Family Recognized by Their Receptors from the Membrane-Bound State?, ChemBioChem, 6, 1520-1534.
  • N. Pradeille, O. Zerbe, K., A. Linden, H. Heimgartner (2005), The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the Azirine/Oxazolone Method, Chemistry and Biodiversity, 2, 1127-1152.
  • K. Weller, S. Lauber, M. Lerch, A. Renaud, H.P. Merkle & O. Zerbe(2005): Biophysical and Biological Studies of End-Group-Modified Derivatives of Pep-1, Biochemistry, 44,15799-15811.
  • M. Herbig, K. Weller, U. Krauss, A. G. Beck-Sickinger, H. P. Merkle & O. Zerbe(2005): Membrane surface associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides, Biophys. J., 89, 4056-4066.


  • S. De Pol, C. Zorn, C. Klein, O. Zerbe*, O. Reiser* (2004), Surprisingly Stable Helical Structures in altering a/b-Peptides by Incorporation of Cis-b-Aminocyclopropane Carboxylic Acids, Angew. Chem. Int. Ed., 43, 511-514.
  • R. Fasan, R.A.L. Dias, K. Möhle, O. Zerbe, J.W. Vrijbloed,D. Obrecht, J. Robinson (2004), Using a b-hairpin to mimic an a-helix: Novel cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction, Angew. Chem. Int. Ed., 43, 2109-2112.
  • M. Lerch, M. Mayrhofer, O. Zerbe (2004), Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors, J. Mol. Biol., 339, 1153-1168.
  • R. Bader, M. Lerch, O. Zerbe (2004) Protein Processing generates both physiologically and pathologically important peptides, PharmaChem, 3, 72-75.
In addition I have been serving as a section editor of Drug Discovery Today (DDT): Technologies for articles describe the use of NMR, Isothermal Titration Calorimetry, Metabonomics, Surface Plasmon Resonance and Analytical Ultracentrifugation for lead optimization, DDT: Technologies 1, 277-315 (on-line journal).



  • J. Scheuermann, A. Volonterio, O. Zerbe, M. Zanda, D. Neri (2003): Discovery and investigation of lead-compounds as binders to the Extra-Domain B of fibronectin, a marker of angiogenesis, Drug Discov. Res., 58, 268-282.
  • O. Zerbe (2003): New developments of NMR Techniques in Pharmaceutical Sciences, Newsmagazine of the American Association of Pharmaceutical Sciences, 6, 18-21.
  • Z. Dzolic, M. Cetina, D. Kovacek, A. Hergold-Brundic, D. Mrvos-Sermek, A. Nagl, N. Slade, K. Pavelic, J. Balzarini, E. De Clercq, O. Zerbe, G. Folkers, L. Scapozza, M. Mintas (2003), Molecular structures and ab initio molecular orbital calculations of the optically active derivatives of 1-aminocyclopropane-1-carboxylic acid, J. Mol. Struct., 655, 229

I have edited a book entitled “BioNMR Techniques in Drug Research” , published by Wiley. In this book, I have co-authored two chapters:
  • D. Moskau, O. Zerbe in BioNMR in Drug Research (Ed. O. Zerbe): Less Noise and Fewer Artifacts in NMR Spectra, pg. 67-78, Wiley-VCH, Weinheim 2002.
  • R. Bader, M. Lerch, O. Zerbe in BioNMR in Drug Research (Ed. O. Zerbe): NMR of Membrane-associated Peptides and Proteins, pg. 95-117, Wiley-VCH, Weinheim 2002.



  • Bader, R., Rytz, G., Beck-Sickinger, A.G., Zerbe, O. (2002): Key Motif to Gain Selectivity at the Neuropeptide Y5-Receptor: Structure and Dynamics of Micelle-Bound [Ala 31 ,Pro 32 ]-NPY, Biochemistry ,41 , 8031-8042.
  • Kaufmann, M., Bozic, D., Briand, C., Bodmer, J.-L., Zerbe, O., Kohl, A., Tschopp, J., Grütter, M.G. (2002): Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling,  FEBS Lett ., 527 , 250-254.
  • Akbay, P., Gertsch, J., Çal s, I., Heilmann, J., Zerbe, O., Sticher, O. (2002): Novel Antileukemic Sterol Glycosides from Ajuga salicifolia ,Helv. Chim. Acta ,85 , 1930-1942.
  • Lerch, M., Gafner, V., Bader, R., Christen, B., Folkers, G., Zerbe, O. (2002): Bovine pancreatic polypeptide (bPP) undergoes significant changes in conformation and dynamics upon binding to DPC micelles, J. Mol. Biol ., 322 , 1117-1133.
  • Romero-Isart, N., Jensen, L.T., Zerbe, O., Winge, D.R., Vasak, M. (2002): Engineering of Metallothionein-3 Neuroinhibitory Activity into the Inactive Isoform Metallothionein-1, J. Biol. Chem ., 277 , 37023-37028.
  • Shankaramma, S.C., Athanassiou, Z., Zerbe, O., Moehle, K., Mouton, C., Bernardini, F., Vrijbloed, J.W., Obrecht, D. and Robinson, J.A. (2002): Macrocyclic Hairpin Mimetics of the Cationic Antimicrobial Peptide Protegrin I: A New Family of Broad-Spectrum Antibiotics, ChemBioChem3, 1126-1133.



  • Liu, A., Luginbühl, P., Zerbe, O., Ortenzi, C., Luporini, P., Wüthrich, K.(2001) : NMR structure of the pheromone Er-22 from Euplotes raikovi ,J. Biomol. NMR. ,19 ,  75-78.
  • Bader, R., Bettio, A., Beck-Sickinger, A., Zerbe, O. (2001): Structure and Dynamics of Micelle-bound Neuropeptide Y: Comparison with unligated NPY and Implications for Receptor Selection, J. Mol. Biol., 305, 307-329.
  • Rognan, D., Mukhija, S., Folkers, G., Zerbe, O. (2001): NMR-restrained docking of a peptide inhibitor to the N-terminal domain of the phosphoenolpyruvate:sugar phospotransferase enzyme1, J. Comp. Aid. Design, 15 , 103-115.
  • Jaki, B., Zerbe, O., Heilman, J.,  Sticher, O. (2001):Two Novel Cyclic Peptides with Antifungal Activity from the Cyanobactyerium Tolypothrix byssoida (EAWAG 195), J. Nat. Prod ., 64 , 154-158.
  • Winkelmann, K., Heilmann, J., Zerbe, O., Rali, T., Sticher, O. (2001):  New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum, J. Nat. Prod ., 64 , 701-706.
  • Demuth, C., Zerbe, O., Rognan, D., Soell, R., Beck-Sickinger, A.G., Folkers, G., Spichiger, U.E. (2001): A rationally designed oligopeptide shows significant conformational changes upon binding to sulphate ions, Biosensors & Bioelectronics ,16 , 783-789. 
  • Romero-Isart, N, Jensen, L.T., Zerbe, O., Vasak, M.(2001):  Engineering of metallothionein-3 neuronal activity into the inactive isoform metallothionein-1: Structural implications, J. Inorg. Biochem. 86 , 406 .
  • Winkelmann, K., Heilmann, J., Zerbe, O., Rali, T., Sticher, O. (2001):  Further prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum, Helv. Chim. Act. 84 , 3380-92. 



  • Winkelmann, K., Heilmann, J., Zerbe, O., Sticher, O. (2000): New Phloroglucinol Derivatives from Hypericum papuanum, J. Nat. Prod. 63 , 104-108.
  • Blanco-Prieto, M.J., Besseghir, K., Zerbe,O., Andris, D., Orsolini, P., Heimgartner, F., Merkle, H.P., Gander, B. (2000): In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres, J. Contr. Rel. 67 , 19-28.
  • Bunke, A., Zerbe, O., Schmid, H., Burmeister, G., Merkle, H.P., Gander, B. (2000): Degradation mechanism and stability of 5-aminolevulinic acid, J. Pharm. Sci. 89, 1335-1341.
  • DeShong P., Soli E.D., Slough G.A. , Sidler D.R., Elango V., Rybczynski P.J., Vosejpka L.J.S., Lessen T.A., Le T.X., Anderson G.B., von Philipsborn W., Vohler M., Rentsch D., Zerbe O. (2000): Glycosylmanganese pentacarbonyl complexes: an organomanganese-based approach to the synthesis of C-glycosyl derivatives, J. Organomet. Chem.  594 ,  49-62.
  • Cabrele,  C., Langer,  M., Bader,  R., Wieland,  H.A.,  Doods,  H.,  Zerbe, O., Beck-Sickinger, A.G. (2000):The First Selective Agonist at the Neuropeptide Y Y5-Receptor Increases Food Intake in Rats, J. Biol. Chem .275 , 36043-36048 .
  • Hasler, D.W., Jensen, L.T., Zerbe, O., Wringe, D.R., Vasak, M. (2000): Effect of two conserved prolines of human growth inhibitory factor (GIF) on its structure and biological activity: comparison with a mutant protein, Biochemistry 39 , 14567-14575 .
  • Bader, R., Lerch, M., Folkers, G., Zerbe, O. (2000): Using Structural Information of Peptides, Derived from NMR Spectroscopy, in Pharmaceutical Chemistry, Chimia, 54 , 627-632.



  • Calis, I., Yusufoglu, H., Zerbe. O., Sticher, O. (1999), Cylocephaloside A: A tridesmosidic cycloartane type glycoside from Astragalus cephalotes var. brevicalyx ,Phytochemistry ,50 , 43-847.
  • Tasdemir, D., Scapozza, L., Zerbe, O., Linden, A., Calis, I. , Sticher, O. (1999): Iridoid Glycosides of Leonurus persicus .J. Nat. Prod .62 , 811-816.
  • Faller, P., Hasler, D., Zerbe, O., Klauser, S., Wringe, D.R., Vasak, M.(1999): Evidence for a Dynamic Structure of Human Neuronal Growth Inhibitory Factor and for Major Rearrangements of its Metal Thiolate Clusters. Biochemistry 38 , 10158 -10167 .
  • Bedir, E., Tasdemir, D., Zerbe, O., Calis, I. , Sticher, O. (1999):Neo-clerodane diterpenoids from Teucrium polium, Phytochemistry 51 , 921-925.
  • Faller, P., Hasler, D.W., Zerbe, O., Vasak, M. (1999): Dynamic structure of metal-thiolate clusters in neuronal growth inhibitory factor (GIF), J. Inorg. Biochem. 74 , 326.



  • Bedir, E., Calis, I. Zerbe. O., Sticher, O. (1998), Cylocephaloside I:A novel Cycloartane-Type Glycoside from Astragalus microcephalus, J. Nat. Prod ., 61 , 503-505.


  • Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, (1997). The NMR solution conformation of unligated human cyclophilin A. J. Mol. Biol. ,272 , 64-81 .


  • P. Luginbühl, J. Wu, O. Zerbe, C. Ortenzi, P. Luporini, K. Wüthrich (1996). The NMR solution structure of the pheromone E r-11 from the ciliated protozoan Euplotes raikovi .Prot. Sci. 5, 1512-1522.
  • O. Zerbe, T. Szyperski, M. Ottiger, K. Wüthrich (1996). Three-dimensional 1H-TOCSY-relayed ct-[ 13 C, 1H]-HMQC for aromatic spin system identification in uniformly 13 C-labelled proteins. J. Biomol. NMR 7, 99-106.
  • B. Rist, O. Zerbe, N. Ingenhoven, L. Scapozza, C. Peers, P.F.T. Vaughan, R.L. McDonald, H.A. Wieland, A.G. Beck-Sickinger (1996). Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y 2-receptor. FEBS Lett. 394 , 169-173.


  • Y. Wang, E.A. Mackay, O. Zerbe, D. Hess, P.E. Hunziker, M. Vasak, J.H.R. Kägi (1995). Characterization and Sequential Localization of the Metal Clusters in Sea Urchin Metallothionein. Biochemistry , 7460-7467.
  • D.L. Pountney,O. Zerbe, W. v. Philipsborn, J.B. Egan, M. Vasak (1995). 3J( 113 Cd, 1H) Couplings in Cd(S-Cys) and Cd-u2(S-Cys)-Cd Moities follow a Karplus-like Dependence with the Hb-Cb-Sg-Cd Torsion Angle: Application to Protein Structure . Bull. J. Magn. Resonance 17 , 145-147.


  • J.H. Welsh, O. Zerbe, W. v. Philipsborn, J.A. Robinson (1992). beta-Turns Induced in Bradykinin by (S)-alpha-Methylproline FEBS Lett. 297 , 216-220.
  • O. Zerbe, J.H. Welsh, J.A. Robinson, W. v. Philipsborn (1992). Complete Assignment of the 1H, 13 C and 15 N Spectra of Bradykinin Derivatives Magn. Reson. Chem. 30, 683-685.
  • O. Zerbe, J.H. Welsh, J.A. Robinson, W. von Philipsborn (1992). A 13 C and 15 N Edited Triple Resonance Experiment. J. Magn. Reson. 100, 329-335.
  • P. DeShong, T.A. Lessen, T.X. Le, G. Anderson, R. Sidler, G.A. Slough, W. v. Philipsborn, M. Vöhler, O. Zerbe (1993). Glycosylmanganese Complexes and Anomeric Anomalies. The next Generation? in: ACS Symposium Series: The Anomeric Effect and Associated Stereoelectronic Effects . Chapt. 12. 227-239.
  • P. Palumaa, O. Zerbe, M. Vasak (1993). Formation and Spectroscopic Characterization of a Novel Monomeric Cadmium-Containing and Phosphate-Containing Form of Metallothionein. Biochemistry 32, 2874-2879.
  • C.J. Henehan, D.L. Pountney, O. Zerbe, M. Vasak (1993). Identification of Cysteine Ligands in Metalloproteins Using Optical and NMR Spectroscopy: Cadmium-Substitued Rubredoxin as a Model [Cd(CysS) 4]2- Center. Prot. Sci. 2, 1756-1764.
  • O. Zerbe, D.L. Pountney, W. v. Philipsborn, M. Vasak (1994). The Magnitude of the Heteronuclear Vicinal Cysteine 1Hb-113 Cd Coupling follows a Karplus-Type Dependence. J. Am. Chem. Soc. 116, 377.
  • M.J. Blommers, D. Nanz, O. Zerbe (1994). Determination of the backbone torsion angle epsilon in nucleis acids. J. Biomol. NMR 4, 595-601.
  • A. Baumeler, O. Zerbe, R.W. Kunz, C.H. Eugster (1994). (6R,9'Z)-Neoxanthin: Synthese, Schmelzverhalten, Spektren und Konformationsberechnungen. Helv. Chim. Acta 77, 909-930.


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