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Department of Chemistry Jason Holland


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Earlier publications

* Corresponding author, † Co-first author

Journal Articles

  1. Eszter Boros,* Jason P. Holland, Nathaniel Kenton, Nicholas Rotile and Peter Caravan

    Macrocycle-based hydroxamate ligands for stable complexation and immunoconjugation of the PET Isotope 89Zr

    ChemPlusChem, 2016, in press. DOI: 10.1002/cplu.201600003.

  2. Svetlana N. Rylova,* Luigi Del Pozzo, Roswitha Tönnesmann, Anna-Lena Illert, Philipp T. Meyer, Helmut R. Maecke and Jason P. Holland

    Immuno-PET imaging of CD-30 positive lymphoma using 89Zr-DFO-AC-10

    J. Nucl. Med., 2016, 57, 96-102. DOI: 10.2967/jnumed.115.162735.

  3. David E. Hill and Jason P. Holland*

    Computational studies on hypervalent iodonium(III) compounds as activated precursors for 18F radiofluorination of electron-rich arenes

    Comput. Theor. Chem., 2015, 1066, 34-56. DOI: 10.1016/j.comptc.2015.05.012.

  4. Steven H. Liang,† Jason P. Holland,† Nickeisha A. Stephenson, Alina Kassenbrock, Benjamin H. Rotstein, Cory Daignault, Rebecca Lewis, Thomas Lee Collier, Jacob M. Hooker and Neil Vasdev*

    PET neuroimaging studies of [18F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and nonhuman primates

    ACS Chem. Neurosci., 2015, 6, 535-541. DOI: 10.1021/acschemneuro.5b00055.

  5. Nickeisha A. Stephenson, Jason P. Holland, Alina Kassenbrock, Daniel L. Yokell, Steven H. Liang and Neil Vasdev*

    Iodonium ylide mediated radiofluorination of 18F-FPEB and validation for human use

    J. Nucl. Med., 2015, 56, 489-492. DOI: 10.2967/jnumed.114.151332.

  6. David E. Hill, Neil Vasdev and Jason P. Holland*

    Evaluating the accuracy of density functional theory for calculating 1H and 13C NMR chemical shifts in drug molecules

    Comput. Theor. Chem., 2015, 1051, 161-173. DOI:10.1016/j.comptc.2014.11.007.

  7. Eszter Boros, Alice M. Bowen, Lee Josephson, Neil Vasdev and Jason P. Holland*

    Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles

    Chem. Sci., 2015, 6(1), 225-236. DOI: 10.1039/C4SC02778G.

  8. Jason P. Holland* and Neil Vasdev

    Charting the mechanism and reactivity of zirconium oxalate with hydroxamate ligands using density functional theory: implications in new chelate design

    Dalton Trans., 2014, 43, 9872-9884. DOI: 10.1039/C4DT00733F. Highlighted as the “Cover Picture,” July 2014.

  9. Eszter Boros,* Elena Rybak-Akimova, Jason P. Holland, Tyson Rietz, Nicholas Rotile,  Francesco Blasi,  Helen Day, Peter Müller and Peter Caravan*

    Pycup – A bifunctional, cage-like ligand for 64Cu radiolabelling

    Mol. Pharmaceuticals, 2014, 1(2), 617-629. DOI: 10.1021/mp400686z.

  10. Neeta Pandit-Taskar,† Joseph A. O’Donoghue,† Volkan Beylergil, Serge Lyaschenko, Shutian Ruan, Steven B. Solomon, Jeremy C. Durack, Jorge A. Carrasquillo, Robert A. Lefkowitz, Mithat Gonen, Jason S. Lewis, Jason P. Holland, Sarah M. Cheal, Victor E. Reuter, Joseph R. Osborne, Massimo F. Loda, Peter M. Smith-Jones, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Michael J. Morris* and Steven M Larson* 89Zr J591 immunoPET imaging in patients with castration-resistant prostate cancer

    Eur. J. Nucl. Med. Mol. Imaging, 2014, 41, 2093-2105. DOI: 10.1007/s00259-014-2830-7.

  11. Jason P. Holland, Steven H. Liang, Benjamin H. Rotstein, Thomas Lee Collier, Nickeisha A. Stephenson, Ivan Greguric and Neil Vasdev*

    Alternative approaches for PET radiotracer development in Alzheimer’s disease: Imaging beyond plaque

    J. Labelled Compds Radiopharm., 2014, 57, 323-331. Highlighted as the “Cover Picture”. 2014. DOI: 10.1002/jlcr.3158.

  12. Benjamin H. Rotstein, Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson and Neil Vasdev*

    11CO2 Fixation: A renaissance in PET radiochemistry

    Chem. Commun., 2013, 49, 5621-5629. DOI: 10.1039/C3CC42236D. Highlighted as the “Cover Picture”. 2013.

  13. Jason P. Holland,* Albert Kang, Susan Cohrs, Svetlana V. Selivanova, Selena Milicevic Sephton, Thomas Betzel, Daniel Frey, Mara Wieser, Rolf Jaussi, Richard A. Kammerer, Roger Schibli and Eliane Fischer*

    Synthesis and evaluation of biphenyl derivatives as kinesin spindle protein inhibitors

    Chem. Biodiversity, 2013, 10(4), 538-555. DOI: 10.1002/cbdv.201200400.

  14. Yelena Y. Janjigian,†* Nerissa Viola-Villegas,† Jason P. Holland, Vadim Divilov, Greg Carbonetti, Sean Carlin, Erica M. Gomes DaGama, Gabriela Chiosis, Elisa de Stanchina and Jason S. Lewis*

    Monitoring afatinib treatment in HER2 positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET

    J. Nucl. Med., 2013, 54, 936-943. DOI: 10.2967/jnumed.112.110239. Featured in a “Health Imaging” press release.

  15. Jason P. Holland,* Michael W. Jones, Susan Cohrs, Roger Schibli and Eliane Fischer*

    Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

    Bioorg. Med. Chem., 2013, 21, 496-507. DOI: 10.1016/j.bmc.2012.11.013.

  16. Jason P. Holland, Paul Cumming and Neil Vasdev*

    PET imaging of enzymes in the brain

    Amer. J. Nucl. Med. Mol. Imaging, 2013, 3(3), 194-216. Link.

  17. Michael J. Evans, Jason P. Holland, Michael G. Doran, Sarah M. Cheal, Carl Campos, Samuel L. Rice, Sean Carlin, Ingo K. Mellinghoff, Charles L. Sawyers and Jason S. Lewis

    Imaging tumor burden in the brain with 89Zr-transferrin

    J. Nucl. Med., 2013, 54(1), 90-95. DOI: 10.2967/jnumed.112.109777. Highlighted as the “Cover Picture,” January 2013.

  18. Jason P. Holland,† Michael J. Evans,† Samuel L. Rice, John Wongvipat, Charles L. Sawyers* and Jason S. Lewis*

    Annotating MYC status with 89Zr-transferrin imaging

    Nature Med., 2012, 18, 1586-1591. DOI: 10.1038/nm.2935. Featured in a SciBX press release.

  19. David Ulmert,† Michael J. Evans,† Jason P. Holland, Samuel L. Rice, John Wongvipat, Kim Pettersson, Per-Anders Abrahamsson, Peter T. Scardino, Steven M. Larson, Hans Lilja, Jason S. Lewis* and Charles L. Sawyers*

    Imaging androgen receptor signaling with a radiotracer targeting prostate specific antigen

    Cancer Discovery, 2012, 2(4), 320-327. DOI: 10.1158/2159-8290.CD-11-0316. Highlighted as the “Cover Picture,” April 2012. Featured in an AACR video press conference and in a “Spotlight” article.

  20. Jason P. Holland,* Paul Cumming and Neil Vasdev

    PET of signal transduction pathways in cancer

    J. Nucl. Med., 2012, 53(9), 1333-1336. DOI: 10.2967/jnumed.112.105387.

  21. Linjing Mu, Cindy R. Fischer, Jason P. Holland, Jessica Becaud,  P. August Schubiger,  Roger Schibli,  Simon M. Ametamey,*  Keith Graham, Timo Stellfeld,  Ludger M. Dinkelborg and Lutz Lehmann

    18F-radiolabeling of aromatic compounds using triarylsulfonium salts

    Eur. J. Org. Chem., 2012, 2012(5), 889-892. DOI: 10.1002/ejoc.201101730.

  22. Alessandro Ruggiero,† Jason P. Holland,† Tvrtko Hudolin,† Larissa Shenker, Anna Koulova, Neil H. Bander, Jason S. Lewis and Jan Grimm*

    PET imaging of therapy-induced prostate cancer cell death by targeting the internal epitope of prostate specific membrane antigen

    J. Nucl. Med., 2011, 52(10), 1608-1615. DOI: 10.2967/jnumed.111.092098.

  23. Jason P. Holland, Guillaume Normand, Alessandro Ruggiero, Jason S. Lewis and Jan Grimm*

    Intra-operative imaging of PET radiotracers using Cerenkov luminescence emissions

    Mol. Imaging, 2011, 10(3), 177-186. DOI: 10.2310/7290.2010.00047.

  24. Carola Heneweer,† Jason P. Holland,† Vadim Divilov, Sean Carlin and Jason S. Lewis*

    Magnitude of enhanced permeability and retention (EPR) effect in tumors with different phenotypes: 89Zr-albumin as a model system

    J. Nucl. Med., 2011, 52(4), 625-633. DOI: 10.2967/jnumed.110.083998.

  25. Alessandro Ruggiero,† Carlos H. Villa,† Jason P. Holland, Shanna R. Sprinkle, Chad May, Jason S. Lewis, David A. Scheinberg and Michael R. McDevitt*

    Imaging and treating tumor vasculature with radiolabeled carbon nanotubes

    Int. J. Nanomedicine, 2010, 5, 783-802. DOI: 10.2147/IJN.S13300.

  26. Inmaculada Matas Ruiz, George R. Whittell, Benjamin M. Partridge, Jason P. Holland, Mairi F. Haddow, Jennifer C. Green* and Ian Manners*

    Synthesis, electronic structure, and reactivity of nickel-, palladium-, and platinum-bridged [1]ferrocenophanes

    J. Amer. Chem. Soc., 2010, 132(38), 13279-13289. DOI: 10.1021/ja103367e.

  27. Jason P. Holland and Jason S. Lewis*

    Zirconium-89 chemistry in the design of novel radiotracers for immuno-PET

    Technetium and Other Radiometals in Chemistry and Medicine, Eds: Ulderico Mazzi, William C. Eckelman, Wynn A. Volkert, Publisher: Servizi Grafici Editoriali snc, Padova, Italy, 2010, 187-192.

  28. Jason P. Holland, Vadim Divilov, Neil H. Bander, Peter M. Smith-Jones, Steven M. Larson and Jason S. Lewis*

    89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo

    J. Nucl. Med., 2010, 51(8), 1293-1300. DOI: 10.2967/jnumed.110.076174. Selected as the Journal of Nuclear Medicine’s Editor’s Choice Award for the “Best Basic Science Article,” June 2011.

  29. Alessandro Ruggiero,† Jason P. Holland,† Jason S. Lewis and Jan Grimm*

    Cerenkov luminescence imaging of medical isotopes

    J. Nucl. Med., 2010, 51(7), 1123-1130. DOI: 10.2967/jnumed.110.076521. Highlighted in a press release by the Society of Nuclear Medicine.

  30. Martin Christlieb,* Jason P. Holland and Jonathan R. Dilworth

    Investigation of the UV–Vis absorption of bis(N-methylthiosemicarbazonato) zinc Zn[ATSM]

    Inorganica Chim. Acta, 2010, 363(6), 1133-1139. DOI: 10.1016/j.ica.2009.10.006.

  31. Artem Y. Lebedev, Jason P. Holland and Jason S. Lewis*

    Clickable bifunctional radiometal chelates for peptide labeling

    Chem. Commun., 2010, 46, 1706-1708. DOI: 10.1039/b924784j.

  32. Jason P. Holland,* and Jennifer C. Green

    Evaluation of exchange-correlation functionals for time-dependent density functional theory calculations on metal complexes

    J. Comput. Chem., 2010, 31(5), 1008-1014. DOI: 10.1002/jcc.21385.

  33. John G. Woollard-Shore, Jason P. Holland, Michael W. Jones* and Jonathan R. Dilworth*

    Nitrite reduction by copper complexes

    Dalton Trans., 2010, 35, 1576-1585. DOI: 10.1039/b913463h.

  34. Jason P. Holland, Eloisi Caldas-Lopes, Vadim Divilov, Valerie M. Longo, Tony Taldone, Danuta Zatorska, Gabriela Chiosis and Jason S. Lewis*

    Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using 89Zr-DFO-trastuzumab

    PLoS ONE, 2010, 5(1), e8859. DOI: 10.1371/journal.pone.0008859.

  35. Jason P. Holland,* Victoria Fisher, Jennie A. Hickin and Josephine M. Peach*

    Pyrene-functionalised copper complexes as potential dual-modality imaging agents

    Eur. J. Inorg. Chem., 2010, (1), 48-58. DOI: 10.1002/ejic.200900823. Highlighted as the “Cover Picture,” January 2010.

  36. Jason P. Holland, Matthew J. Williamson and Jason S. Lewis*

    Unconventional nuclides for radiopharmaceuticals

    Mol. Imaging, 2010, 9(1), 1-20. DOI: 10.2310/7290.2010.00008.

  37. Jason P. Holland,* Michael W. Jones, Paul D. Bonnitcha, Jason S. Lewis and Jonathan R. Dilworth

    Functionalised copper-64 bis(thiosemicarbazonato) complexes as precursors of potential PET imaging agents for neurodegenerative disorders

    New J. Chem., 2009, 33, 1845-1852. DOI: 10.1039/b902895a. Top 10 New J. Chem. downloaded articles, September 2009.

  38. Jason P. Holland, Yiauchung Sheh and Jason S. Lewis*

    Standardized methods for the production of high specific-activity zirconium-89

    Nucl. Med. Biol., 2009, 36, 729-739. DOI: 10.1016/j.nucmedbio.2009.05.007. #1 Highest cited article in NMB since 2009.

  39. Peter J. Barnard,* Jason P. Holland, Simon R. Bayly, Thaddeus J. Wadas, Carolyn J. Anderson and Jonathan R. Dilworth*

    Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agents

    Inorg. Chem., 2009, 48(15), 7117-7126. DOI: 10.1021/ic900307f.

  40. Georgeta Masson, David E. Herbert, George R. Whittell, Jason P. Holland, Alan J. Lough, Jennifer C. Green* and Ian Manners*

    Synthesis and reactivity of a silicon-bridged [1]ferroceniumphane

    Angew. Chem. Int. Ed., 2009, 48, 4961-4964. DOI: 10.1002/anie.200901213.

  41. Franziska Bell, Jason Holland, Jennifer C. Green* and Michel R. Gagné

    Computational studies on the Pt(II)-catalyzed cycloisomerization of 1,6-dienes into bicyclopropanes: A mechanistic quandary evaluated by DFT

    Organometallics, 2009, 28, 2038-2045. DOI: 10.1021/om800770x.

  42. Jason P. Holland,* Jeffrey H. Giansiracusa, Stephen G. Bell, Luet-Lok Wong and Jonathan R. Dilworth

    In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals

    Phys. Med. Biol., 2009, 54, 2103-2119. DOI: 10.1088/0031-9155/54/7/017.

  43. Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth and Jennifer C. Green

    Electronic absorption spectroscopy and time-dependent density functional theory calculations on the nickel(II) complex of 1,4-bis(pyrrol-2-ylmethyleneamino)butane

    Inorganica Chim. Acta, 2009, 362(2), 402-406. DOI: 10.1016/j.ica.2008.04.031.

  44. Jason P. Holland, Riccardo Ferdani, Carolyn J. Anderson and Jason S. Lewis*

    Copper-64-radiopharmaceuticals for oncologic imaging

    PET Clinics, 2009, 4(1), 49-67. DOI: 10.1016/j.cpet.2009.04.013.

  45. Jason P. Holland, Jason S. Lewis and Farrokh Dehdashti*

    Assessing tumor hypoxia by positron emission tomography with Cu-ATSM

    Q. J. Nucl. Med. Mol. Imaging, 2009, 53, 193-200. Link.

  46. Jason P. Holland,* Jennie A. Hickin, Emma Grenville-Mathers, ThaoNguyen Nguyen, and Josephine M. Peach*

    Rapid decomplexation of bis(thiosemicarbazonato)zinc(II) complexes using citric acid

    J. Chem. Res., 2008, 12, 702-703. DOI: 10.3184/030823408X380731.

  47. Simon R. Bayly, Robert C. King, Davina J. Honess, Peter J. Barnard, Helen M. Betts, Jason P. Holland, Rebekka Hueting, Paul D. Bonnitcha, Jonathan R. Dilworth, Franklin I. Aigbirhio, and Martin Christlieb*

    In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)–glucose conjugate for hypoxia imaging

    J. Nucl. Med., 2008, 49, 1862-1868. DOI: 10.2967/jnumed.108.054015.

  48. Helen M. Betts, Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth,* Antony D. Gee and Jason P. Holland

    Controlled axial ligation: solid-phase synthesis and purification of metallo-radiopharmaceuticals

    Angew. Chem. Int. Ed., 2008, 47(44), 8416-8419. DOI: 10.1002/anie.200801936.

  49. Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* Julia M. Heslop, Eric J. L. McInnes, Christoph G. Salzmann and Amber L. Thompson

    Synthesis, X-ray crystallography, spectroelectrochemistry and computational studies on potential copper-based radiopharmaceuticals

    Eur. J. Inorg. Chem., 2008, 3549-3560. Highlighted as a “EurBest” article, 20th August 2008. DOI: 10.1002/ejic.200800413.

  50. Jason P. Holland, Peter J. Barnard, Jonathan R. Dilworth,* and David J. Watkin


    Acta Crystallogr. E, 2008, E64, m773. DOI: 10.1107/S1600536808010684.

  51. Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* and Eric J. L. McInnes

    Spectroelectrochemical and computational studies on the mechanism of hypoxia-selectivity of copper radiopharmaceuticals

    Chem. Eur. J., 2008, 14, 5890-5907. DOI: 10.1002/chem.200800539.

  52. Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Helen M. Betts, Grant C. Churchill, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green* and Rebekka Hueting

    Synthesis, radiolabelling and confocal fluorescence microscopy of styrene derivatised zinc and copper bis(thiosemicarbazonato) complexes

    Eur. J. Inorg. Chem., 2008, 1985-1993. DOI: 10.1002/ejic.200701351.

  53. Peter J. Barnard, Simon R. Bayly, Jason P. Holland, Jonathan R. Dilworth* and Philip A. Waghorn

    In vitro assays for assessing the stability of new potential copper-based radiopharmaceuticals

    Q. J. Nucl. Med. Mol. Imaging, 2008, 52(3), 235-244. Link.

  54. Peter Barnard, Simon Bayly, Helen Betts, Paul Bonnitcha, Martin Christlieb, Jon Dilworth,* Jason Holland and Sofia Pascu

    Towards new copper based radiopharmaceuticals

    Q. J. Nucl. Med. Mol. Imaging, 2008, 52(2), 174-184. Link.

  55. Andrey Y. Khalimon, Jason P. Holland, Radoslaw M. Kowalczyk, Eric J. L. McInnes, Jennifer C. Green, Philip Mountford* and Georgii Nikonov

    Synthesis and molecular and electronic structure of an unusual paramagnetic borohydride complex Mo(NAr)2(PMe3)2(h2-BH4)

    Inorg. Chem., 2007, 47, 999-1006. DOI: 10.1021/ic701826v.

  56. Jason P. Holland, Franklin I. Aigbirhio, Helen M. Betts, Paul D. Bonnitcha, Paul Burke, Martin Christlieb, Grant C. Churchill, Andrew R. Cowley, Jonathan R. Dilworth,* Paul S. Donnelly, Jennifer C. Green, Josephine M. Peach, Sridhar R. Vasudevan and John E. Warren

    Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: Synthetic platforms towards site-specific radiopharmaceuticals

    Inorg. Chem., 2007, 46, 465-485. DOI: 10.1021/ic0615628.

  57. Jason P. Holland, Jennifer C. Green* and Jonathan R. Dilworth*

    Probing the mechanism of hypoxia-selectivity of copper bis(thiosemicarbazonato) complexes: DFT calculation of redox potentials and absolute acidities in solution

    Dalton Trans., 2006, 6, 783-794. DOI: 10.1039/b512656h. Highlighted as a “Hot Article” and reviewed in Chemistry World, January 2006.

  58. Andrei S. Batsanov, Jonathan C. Collings, Ian J. S. Fairlamb,* Jason P. Holland, Judith A. K. Howard, Zhenyang Lin, Todd B. Marder,* Alex C. Parsons, Richard M. Ward, and Jun Zhu

    Requirement for an oxidant in Pd/Cu co-catalyzed terminal alkyne homocoupling to give symmetrical 1,4-disubstituted 1,3-diynes

    J. Org. Chem., 2005, 70, 703-706. DOI: 10.1021/jo048428u.

Books and Chapters

  1. Jason Holland

    Hypoxia-Selective Copper Radiopharmaceuticals: Rational Design of Novel Imaging Agents

    VDM-Verlag, Germany, 15th May 2009. ISBN-13: 978-3-639-15244-9. ISBN-10: 3639152441. (Thesis book)


  3. Brian M. Zeglis, Jason P. Holland, Artem Y. Lebedev, Melchor V. Cantorias and Jason S. Lewis

    Radiopharmaceuticals for imaging in oncology with special emphasis on positron-emitting agents

    Chapter 3 in Nuclear Oncology – Pathophysiology and Clinical Applications, Eds. H. William Strauss, Giuliano Mariani, Duccio Volterrani, Steven M. Larson. Springer. 2012. ISBN-13: 978-0387488936. ISBN-10: 0387488936. (Book chapter)