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Department of Chemistry Nina Hartrampf

Publication List

Publication List on ORCID

Publication List on Google Scholar

At UZH

  1. “Development of ArgTag for scalable solid-phase synthesis of aggregating peptides”
    V. Freiburghaus, A. Jeandin, L. Frankiewicz, J. Yang, N. Hartrampf
    ChemRxiv 2025, DOI: https://doi.org/10.26434/chemrxiv-2025-17x7m-v2.
     
  2. “Automated Structure Elucidation at Human-Level Accuracy via a Multimodal Multitask Language Model”
    M. Alberts, N. Hartrampf, T. Laino
    ChemRxiv 2025, DOI: 10.26434/chemrxiv-2025-q80r9.
     
  3. “Amino Acid Composition drives Peptide Aggregation: Predicting Aggregation for Improved Synthesis”
    B. Tamás,‡ M. Alberts,‡ T. Laino, N. Hartrampf (‡ = authors contributed equally)
    ChemRxiv 2025, DOI: 10.26434/chemrxiv-2025-wjbmv.
     
  4. “From Spectra to Structure: AI-Powered 31P-NMR Interpretation”
    M. Alberts, N. Hartrampf, T. Laino
    Analytical Chemistry 2025 97 (29), 15736-15742
     
  5. “Unraveling Molecular Structure: A Multimodal Spectroscopic Dataset for Chemistry”
    M. Alberts, O. Schilter, F. Zipoli, N. Hartrampf, T. Laino
    Adv. Neural Inf. Process Syst. 2024, 37, 125780–125808.
     
  6. “A versatile “Synthesis Tag” (SynTag) for the chemical synthesis of aggregating peptides and proteins”
    H. Bürgisser,‡ E. T. Williams,‡ A. Jeandin, R. Lescure, A. Premanand, S. Wang, N. Hartrampf (‡ = authors contributed equally)
    J. Am. Chem. Soc. 2024, 146 (50), 34887–34899.
     
  7. “Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides”
    K. Schiefelbein, J. Lang, M. Schuster, C. E. Grigglestone, R. Striga, L. Bigler, M. C. Schuman, O. Zerbe, Y. Li, N. Hartrampf
    J. Am. Chem. Soc. 2024, 146 (25), 17261–17269.
     
  8. "Rapid Flow-Based Synthesis of Post-Translationally Modified Peptides and Proteins: A Case Study on MYC’s N-terminus"
    E. T. Williams, K. Schiefelbein, M. Schuster, I. M. M. Ahmed, M. De Vries, R. Beveridge, O. Zerbe, N. Hartrampf
    Chem. Sci. 2024, 15, 8756–8765.
     
  9. "Probing PAC1 receptor activation across species with an engineered sensor"
    R. B. Cola, S. N. Niethammer, P. Rajamannar, A. Gresch, M. A. Bhat, K. Assoumou, E. T. Williams, P. Hauck, N. Hartrampf, D. Benke, M. Stoeber, G. Levkowitz, S. Melzer, T. Patriarchi
    eLife 2024, 13:RP96496.
     
  10. “A robust data analytical method to investigate sequence-dependence in flow-based peptide synthesis”
    B. Tamás,‡ P. L. Willi,‡ H. Bürgisser, N. Hartrampf (‡ = authors contributed equally)
    React. Chem. Eng. 2024, 9, 825-832
     
  11. “Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution”
    L. Duffet,‡ E. T. Williams,‡ A. Gresch, S. Chen, M. A Bhat, D. Benke, N. Hartrampf, T. Patriarchi
    (‡ = authors contributed equally)
    eLife 2023,  12:RP86628.
     
  12. “A photocaged orexin-B for spatiotemporally precise control of orexin signaling”
    L. Duffet,‡ P. V. Tatarskiy,‡ M. Harada,‡ E. T. Williams, N. Hartrampf, T. Patriarchi
    (‡ = authors contributed equally)
    Cell Chem. Bio 2022, 29, 1729.
     
  13. “Flow-Based Methods in Chemical Peptide and Protein Synthesis”
    K. Schiefelbein, N. Hartrampf
    CHIMIA 2021, 75, 480.
     
  14. “Flow-based SPPS for protein synthesis: A perspective”
    Z. P. Gates, N. Hartrampf
    Pept. Sci. 2020, e24198.
     

Postdoctoral, Graduate, and Undergraduate Research


  1. "How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins"
    M. C. Baxa, X. Lin, C. D. Mukinay, S. Chakravarthy, J. R. Sachleben, S. Antilla, N. Hartrampf, J. A. Riback, I. A. Gagnon, B. L. Pentelute, P. L. Clark, T. R. Sosnick
    Prot. Sci. 2024, 33, 5, e4986.
     
  2. "Structural Diversity of Photoswitchable Sphingolipids for Optodynamic Control of Lipid Raft Microdomain"
    N. Hartrampf,‡ S. M. Leitao,‡ N. Winter, H. Toombs-Ruane, J. A. Frank, P. Schwille, D. Trauner, H. G. Franquelim
    (‡ = authors contributed equally)
    Biophys. J. 2023, 122, 11, 2325–2341.
     
  3. “Rapid Single-Shot Synthesis of the 217 Amino Acid-Long N-Terminal Domain of Pyocin S2”
    A. Saebi,‡ J. S. Brown,‡ V. M., Marando, N. Hartrampf, N. M. Chumbler, S. Hanna, M. Poskus; A. Loas, L. L. Kiessling, D. T. Hung, B. L. Pentelute*
    (‡ = authors contributed equally)
    ACS Chem. Biol. 2023, 18, 3, 518–527.
     
  4. "A Tumor-Homing Peptide Platform enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma"
    C.-F. Cho,* C. E. Farquhar, C. M. Fadzen, B. Scott, P. Zhuang, N. v. Spreckelsen, A. Loas, N. Hartrampf, B. L. Pentelute, S. E. Lawler
    Cancers 2022, 14, 2207.
     
  5. “Automated Flow Synthesis of Peptide-PNA Conjugates”
    C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute*
    ACS Cent. Sci 2022, 8, 2, 205.
     
  6. "Fully Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers"
    C. Li,‡ A. J. Callahan,‡ M. D. Simon, K. A. Totaro, A. J. Mijalis, N. Hartrampf, C. K. Schissel, M. Zhou, H. Zong, Gunnar J. Hanson, A. Loas, N. L. B. Pohl, B. L. Pentelute
    (‡ = authors contributed equally)
    Nat. Commun. 2021, 12, 4396
     
  7. Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican
    N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho
    Adv. Ther. 2021, 4, 2000244
     
  8. Identification of N-terminally diversified GLP-1R agonists using saturation mutagenesis and chemical design
    C. K. Longwell, S. Hanna, N. Hartrampf, R. A. Parra Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran
    ACS Chem. Biol. 2021, 16, 1, 58–66
     
  9. Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis
    S. Mohapatra,‡ N. Hartampf,‡ M. Poskus, R. Gomez-Bombarelli, B. L. Pentelute
    (‡ = authors contributed equally)
    ACS Cent. Sci. 2020, 6, 2277–2286
     
  10. Ultra-large chemical libraries for the discoveryof high-affinity peptide binders
    A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute
    Nat. Commun. 2020, 11, 3183
     
  11. Synthesis of Proteins by Automated Flow Chemistry
    N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute (‡ = authors contributed equally)
    Science , 2020, 368, 980-987 
    This work was highlighted by others in:
    • Science Perspective: C. Proulx, Science 2020, 368, 941
    • Synfacts: D. Trauner, B. S. Matsuura, Synfacts2020 , 16, 1129 (selected as “Synfact of the month”)
    MIT News, Chemistry World, CE&N and others.
     
  12. “Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of Cytokine Production”
    N. Hartrampf, T, Seki, A. Baumann, P. Watson, N. A. Veprek, B. Hetzler, A. Hoffmann-Röder, M. Tsuji, D. Trauner
    Chem. Eur. J. 2020, 26, 4476-4479
     
  13. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine
    N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner
    J. Am. Chem. Soc. 2018, 140, 8675–8680.
    Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 
     
  14. Light control of L-type Ca2+ channels using a diltiazem photoswitch
    T. Fehrentz, F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H.F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner
    Nat. Chem. Biol. 2018, 14, 764–767. 
     
  15. "Synthetic Approaches towards Alkaloids Bearing α-Tertiary Amines"
    A. Hager,‡ N. Vrielink, ‡ D. Hager, J. Lefranc, D. Trauner (‡ = authors contributed equally)
    Nat. Prod. Rep. 2016, 33, 491–522. 
     
  16. "Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex"
    C. H. Douse, N. Vrielink, Z. Wenlin, E. Cota, E. W. Tate
    ChemMedChem, 2015, 10, 134-143. 

Perspectives and Conference Reports

“The Swiss Summer School on Chemical Biology, Bergün/Bravuogn, August 25–29, 2024; Part A: Inspiring Science in an Inspiring Environment”
H. P. Lüthi, D. Gillingham, N. Hartrampf, J.-L. Reymond
CHIMIA 2024, 78, 793–794.

“Trendberichte Biochemie: Chemische Proteinsynthese”
N. Hartrampf
Nachr. Chem. 2024, 72, 56–58.

“Peptide Therapeutics Forum 2023”
N. Hartrampf
CHIMIA 2023, 77, 877–878.

“Reflections on Navigating a Pandemic: Perspectives from the Chemical Biology Community” (Editorial for the ChemBioTalents special issue)
A. C. Conibear, N. Hartrampf
ChemBioChem 2023, e202300258.

“An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society”
Y. P. Auberson,* F. Benfatti, D. Gillingham, N. Hartrampf
ChemMedChem 2023, 18, e202300014.

“DMCCB Basel Symposium 2022 - Intrinsically Disordered Proteins as Drug Targets”
E. T. Williams, N. Hartrampf*
CHIMIA 2022, 76, 493.

“The Young Faculty Meeting 2021 - A Focus on Group Management”
J. de Roo, N. Hartrampf, L. Merz
CHIMIA 2021, 75, 692–694.

"Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany”
C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear
Cell Chem. Biol. 2019, 26, 1349–1354.