Our research combines organic chemistry, automated flow synthesis, and chemical biology to study natural and artificial biopolymers. We aim to address fundamental synthetic challenges and apply biopolymers in a variety of contexts.
Sequence-defined polymers, including peptides and proteins, play crucial roles in every aspect of life. Their chemical synthesis allows for the incorporation of non-canonical amino acids, post-translational modifications, modified backbones and functional handles, but requires highly efficient transformations for the incorporation of every single building block.
Continuous-flow synthesis is gaining momentum due to the precise control over reaction parameters and the possibility for automated in-line analytical monitoring. We use flow chemistry to develop efficient reactions and synthesize non-natural building blocks for the production of sequence-defined polymers. We are interested in studying all components of the system - including the development of new technology and biological applications of the synthetic products.
Our goal is to ultimately provide tailored peptidic natural products, proteins and related functional polymers on demand.