Publications
ZORA Publication List
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Publications
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2025
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Journal Article
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Elucidating the solution structure of the monomolecular $BCL2$ RNA G-quadruplex: a new robust NMR assignment approach Chemical Science, 16, 9669–9678. https://doi.org/10.1039/d5sc01416f
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2024
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Journal Article
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Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy Journal of Visualized Experiments, e67391. https://doi.org/10.3791/67391
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Corrin Ring Modifications Reveal the Chemical and Spatial Requirements for the B$_1$$_2$ $btuB$ Riboswitch Interaction Chemistry, 30, e202401800. https://doi.org/10.1002/chem.202401800
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FRET-guided modeling of nucleic acids Nucleic Acids Research, 52, e59. https://doi.org/10.1093/nar/gkae496
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Reply to: On the statistical foundation of a recent single molecule FRET benchmark Nature Communications, 15, 3626. https://doi.org/10.1038/s41467-024-47734-2
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From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes Chimia, 78, 200–204. https://doi.org/10.2533/chimia.2024.200
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Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages Nature Communications, 15, 1559. https://doi.org/10.1038/s41467-024-45653-w
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Dissertation
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A Tale of Two Self-Splicing Pathways (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-263221
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Investigation of the Binding Requirements of the $\textit{moaA}$ Riboswitch (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-263129
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Illuminating the Structure-Function Relationship of Group II Introns (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-263159
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Short Peptides as Selective Chelating Agents for Lead Detoxification (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259350
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From Bioinspired Scaffolds to Genetically Encoded Libraries: The Quest for Next-Generation Chelating Agents for Lead (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259349
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Edited Scientific Work
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Metal-Containing Molecules and Nanomaterials: From Diagnosis to Therapy (Vol. 26). CRC Press, Taylor & Francis Group.
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2023
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Journal Article
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Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks Journal of the American Chemical Society, 145, 13570–13580. https://doi.org/10.1021/jacs.3c00118
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The structural features of the ligand-free moaA riboswitch and its ion-dependent folding Journal of Inorganic Biochemistry, 242, 112153. https://doi.org/10.1016/j.jinorgbio.2023.112153
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Group II Introns: Highly Structured yet Dynamic Chimia, 77, 235–241. https://doi.org/10.2533/chimia.2023.235
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Dissertation
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Probing the CPEB3 ribozyme structure by nuclear magnetic resonance (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-257011
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2022
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Journal Article
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A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories Nature Communications, 13, 5402. https://doi.org/10.1038/s41467-022-33023-3
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Magnesium(II)-ATP Complexes in 1-Ethyl-3-Methylimidazolium Acetate Solutions Characterized by 31Mg β-Radiation-Detected NMR Spectroscopy Angewandte Chemie Internationale Edition, 61, e202207137. https://doi.org/10.1002/anie.202207137
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Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations Molecules, 27, 2625. https://doi.org/10.3390/molecules27092625
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Book Section
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Chemical Dual End-Labeling of Large Ribozymes In G. Steger, H. Rosenbach, & I. Span (Eds.), DNAzymes : Methods and Protocols (pp. 191–204). Springer. https://doi.org/10.1007/978-1-0716-2047-2_13
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Metal ion interactions with nucleic acids In D. Black (Ed.), Reference Module in Chemistry, Molecular Sciences and Chemical Engineering / 2022 (p. online). Elsevier. https://doi.org/10.1016/b978-0-12-823144-9.00176-x
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Single-Molecule Kinetic Studies of Nucleic Acids by Förster Resonance Energy Transfer In G. Steger, H. Rosenbach, & I. Span (Eds.), DNAzymes : Methods and Protocols (pp. 173–190). Springer. https://doi.org/10.1007/978-1-0716-2047-2_12
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Dissertation
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Exploring the effects of error-prone protein synthesis on neuronal homeostasis and aging (Dissertation, University of Zurich)
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2021
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Journal Article
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FRETraj: integrating single-molecule spectroscopy with molecular dynamics Bioinformatics, 37, 3953–3955. https://doi.org/10.1093/bioinformatics/btab615
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Puf6 primes 60S pre-ribosome nuclear export at low temperature Nature Communications, 12, 4696. https://doi.org/10.1038/s41467-021-24964-2
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Screening for potential interaction partners with surface plasmon resonance imaging coupled to MALDI mass spectrometry Analytical Biochemistry, 624, 114195. https://doi.org/10.1016/j.ab.2021.114195
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Dissertation
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Structural Investigation of RNA G-quadruplex and the Interaction with Small Molecules (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-230597
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CPEB3 Ribozymes Adopt an Unexpected Fold: From Monomer to Dimer and Back (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-215277
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2020
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Journal Article
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Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts Nature Communications, 11, 104. https://doi.org/10.1038/s41467-019-13683-4
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Book Section
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Site-Specific Dual-Color Labeling of Long RNAs In T. Heise (Ed.), RNA Chaperones (No. 2106; pp. 253–270). Springer. https://doi.org/10.1007/978-1-0716-0231-7_16
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Encapsulation of Fluorescently Labeled RNAs into Surface-Tethered Vesicles for Single-Molecule FRET Studies in TIRF Microscopy In V. Arluison & F. Wien (Eds.), RNA Spectroscopy (No. 2113; pp. 1–16). Springer. https://doi.org/10.1007/978-1-0716-0278-2_1
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Dissertation
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Design, Synthesis, and Biological Evaluation of Next Generation Fidaxomicin Antibiotics (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-199264
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Droplet Assisted Growth and Shaping: A broadly applicable chemical synthesis method for in situ shaping of multiple nanostructures (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-198854
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Single-Molecule FRET Guided Modeling of RNA Structure and Dynamics (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-199191
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Light-Induced Protein Conformational Changes Studied by Two-Dimensional Infrared and Transient Infrared Spectroscopies (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-198865
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Synthetic and Catalytic Investigations of Homo- and Heterometallic Cobalt Cubanes as Water Oxidation Catalysts (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-194391
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2019
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Journal Article
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Concerted dynamics of metallo-base pairs in an A/B-form helical transition Nature Communications, 10, 4818. https://doi.org/10.1038/s41467-019-12440-x
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NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance Nucleic Acids Research, 47, 4872–4882. https://doi.org/10.1093/nar/gkz197
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Stick, Flick, Click: DNA-guided Fluorescent Labeling of Long RNA for Single-molecule FRET Chimia, 73, 257–261. https://doi.org/10.2533/chimia.2019.257
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The Bioinorganic Periodic Table Chimia, 73, 185–193. https://doi.org/10.2533/chimia.2019.185
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Dissertation
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Exploring the Phenotype of Mrps5-Associated Mitochondrial Mistranslation (Dissertation, University of Zurich)
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Biomedical Studies on Chitosan Materials and Polyoxometalate Nanocomposites as Versatile Anticancer and Antimicrobial Drug Prototypes (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-194375
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Hunting for the identity of the missing metabolite of the Moco riboswitch (Dissertation, University of Zurich)
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Synthesis, Derivatisation and Characterisation of Rhenium Mono- and Bis(η6-Benzoic Acid) Complexes as Potential Bioorganometallic Building Blocks (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-194376
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2018
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Journal Article
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Optimal molecular crowding accelerates group II intron folding and maximizes catalysis Proceedings of the National Academy of Sciences of the United States of America, 115, 11917–11922. https://doi.org/10.1073/pnas.1806685115
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Simulations of camera-based single-molecule fluorescence experiments PLoS ONE, 13, e0195277. https://doi.org/10.1371/journal.pone.0195277
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Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy Nucleic Acids Research, 46, e13–e13. https://doi.org/10.1093/nar/gkx1100
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Reliable State Identification and State Transition Detection in Fluorescence Intensity-Based Single-Molecule Förster Resonance Energy-Transfer Data Journal of Physical Chemistry B, 122, 6134–6147. https://doi.org/10.1021/acs.jpcb.7b12483
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Celebrating Helmut Sigel Journal of Biological Inorganic Chemistry, 23, 1–5. https://doi.org/10.1007/s00775-017-1523-7
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Metal ion complexes of nucleoside phosphorothioates reflecting the ambivalent properties of lead(ii) New Journal of Chemistry, 42, 7551–7559. https://doi.org/10.1039/C7NJ04989G
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Covalent and non-covalent binding of platinated vitamin B 12 -derivatives to a B 12 responsive riboswitch Inorganica Chimica Acta, 472, 214–220. https://doi.org/10.1016/j.ica.2017.09.018
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Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding Journal of Biological Inorganic Chemistry, 23, 167–177. https://doi.org/10.1007/s00775-017-1519-3
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Dissertation
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From chitosan thiomers to polyoxometalate-chitosan nanocomposites for medical applications (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-157425
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Combining single-molecule with ensemble fluorescence experiments to disentangle the interplay of folding and activity of a group II intron ribozyme (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-153071
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Characterization of metal-mediated base pairs in duplex DNA using fluorescent nucleoside analogs and NMR spectroscopy (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-153019
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⁹⁹mTc- and Re-based target specific multimodality (nano)particles (Dissertation, University of Zurich)
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Silicone nanostructures for antibacterial and antifungal applications (Dissertation, University of Zurich)
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2017
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Journal Article
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Tb3+-Cleavage Assays Reveal Specific Mg2+ Binding Sites Necessary to Pre-fold the btuB Riboswitch for AdoCbl Binding Frontiers in Chemistry, 5, 598. https://doi.org/10.3389/fchem.2017.00010
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G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs Inorganic Chemistry Frontiers, 4, 10–32. https://doi.org/10.1039/C6QI00300A
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Influence of pH and Mg(ii) on the catalytic core domain 5 of a bacterial group II intron Dalton Transactions, 46, 3989–3995. https://doi.org/10.1039/c6dt04784j
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Book Section
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The Role of Lead(II) in Nucleic Acids In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Lead: Its Effects on Environment and Health (No. 17; pp. 403–434). De Gruyter. https://doi.org/10.1515/9783110434330-012
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Dissertation
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Unravelling the Interaction of a Re(I)dppz Metallo-Intercalator with an RNA Internal Loop (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-147187
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Vesicle Encapsulation and Data Analysis Standardization to Characterize Large Catalytic RNAs Using Single Molecule FRET (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-147192
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The Influence of Mg2+ on a Single RNA Tertiary Contact (Dissertation, University of Zurich)
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Chemistry of cyclometalated gold(III) complexes: outfit for mechanistic investigations and beyond (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-142925
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Edited Scientific Work
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Metal Ions in Life Sciences (Vols. 5–9, 17). De Gruyter. https://www.degruyter.com/view/serial/462281
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2016
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Journal Article
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The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations International Journal of Molecular Sciences, 17, 988. https://doi.org/10.3390/ijms17070988
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Secondary structure confirmation and localization of Mg2+ions in the mammalian CPEB3 ribozyme RNA, 22, 750–763. https://doi.org/10.1261/rna.053843.115
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An atomistic view on carbocyanine photophysics in the realm of RNA Physical Chemistry Chemical Physics (PCCP), 18, 29045–29055. https://doi.org/10.1039/c6cp04277e
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Metal ion binding to an RNA internal loop Inorganica Chimica Acta, 452, 104–110. https://doi.org/10.1016/j.ica.2016.02.050
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Sequence-specific post-synthetic oligonucleotide labeling for single-molecule fluorescence applications ACS Chemical Biology, 11, 2558–2567. https://doi.org/10.1021/acschembio.6b00343
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Metal ion induced heterogeneity in RNA folding studied by smFRET Coordination Chemistry Reviews, 327–328, 123–142. https://doi.org/10.1016/j.ccr.2016.06.002
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Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes Journal of Biological Inorganic Chemistry, 21, 975–986. https://doi.org/10.1007/s00775-016-1393-4
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Characterization of the full-length btuB riboswitch from Klebsiella pneumoniae Journal of Inorganic Biochemistry, 160, 106–113. https://doi.org/10.1016/j.jinorgbio.2015.12.012
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Studying metal ion binding properties of a three-way junction RNA by heteronuclear NMR Journal of Biological Inorganic Chemistry, 21, 319–328. https://doi.org/10.1007/s00775-016-1341-3
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Edited Scientific Work
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Metal Ions in Life Sciences (Vols. 10–16). Springer. http://www.springer.com/series/8385
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2015
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Journal Article
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Protonation-Dependent Base Flipping at Neutral pH in the Catalytic Triad of a Self-Splicing Bacterial Group II Intron Angewandte Chemie Internationale Edition, 54, 9687–9690. https://doi.org/10.1002/anie.201504014
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Cation-induced kinetic heterogeneity of the intron–exon recognition in single group II introns Proceedings of the National Academy of Sciences of the United States of America, 112, 3403–3408. https://doi.org/10.1073/pnas.1322759112
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Explicit analytic equations for multimolecular thermal melting curves Biophysical Chemistry, 202, 32–39. https://doi.org/10.1016/j.bpc.2015.04.001
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Mimicking the in vivo Environment – The Effect of Crowding on RNA and Biomacromolecular Folding and Activity Chimia, 69, 207–212. https://doi.org/10.2533/chimia.2015.207
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Internal Labeling Strategy of Large RNAs with Minimal Perturbation Using Fluorescent PNA Chembiochem, 16, 1302–1306. https://doi.org/10.1002/cbic.201500180
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Preface for the JIB Special Issue for the 12th European Biological Inorganic Chemistry Conference (EuroBIC 12) in Zurich, Switzerland, August 24–28, 2014 Journal of Inorganic Biochemistry, 148, 1. https://doi.org/10.1016/j.jinorgbio.2015.06.013
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Book Section
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Metal Ions in Ribozymes and Riboswitches In E. Stulz & G. H. Clever (Eds.), DNA in Supramolecular Chemistry and Nanotechnology (pp. 412–433). John Wiley & Sons Ltd. https://doi.org/10.1002/9781118696880.ch5
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2014
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Journal Article
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Preface Journal of Biological Inorganic Chemistry, 19(S2):699.
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Synthesis, structure, physico-chemical and biological properties of metal(II) complexes with 5-amino-8-methyl-4H-benzopyran-4-one Polyhedron, 67, 136–144. https://doi.org/10.1016/j.poly.2013.08.071
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The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: Solution structure and metal ion binding sites of the RNA{middle dot}DNA complex Journal of Biological Chemistry, 289, 20650–20663. https://doi.org/10.1074/jbc.M113.542381
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Synthesis, physico-chemical properties and biological analysis of newly obtained copper(II) complexes with pyrazole derivatives Journal of Inorganic Biochemistry, 135, 68–76. https://doi.org/10.1016/j.jinorgbio.2014.02.014
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Structure determination of noncanonical RNA motifs guided by $^1$H NMR chemical shifts Nature Methods, 11, 413–416. https://doi.org/10.1038/nmeth.2876
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Mg(2+)-induced conformational changes in the btuB riboswitch from E. coli RNA, 20, 36–45. https://doi.org/10.1261/rna.039909.113
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Photo-induced uncaging of a specific Re(I) organometallic complex in living cells Chemical Science, 5, 4044–4056. https://doi.org/10.1039/C3SC53550A
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NMR structure of the 5’ splice site in the group IIB intron Sc.ai5 - conformational requirements for exon-intron recognition. RNA, 20, 295–307. https://doi.org/10.1261/rna.041137.113
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Solution structure and metal ion binding sites of the human CPEB3 ribozyme’s P4 domain Journal of Biological Inorganic Chemistry, 19, 903–912. https://doi.org/10.1007/s00775-014-1125-6
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Book Section
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The AdoCbl–Riboswitch Interaction Investigated by In-Line Probing and Surface Plasmon Resonance Spectroscopy (SPR) In D. H. Burke-Aguero (Ed.), Riboswitch Discovery, Structure and Function (No. 549; Vol. 549, pp. 467–488). Elsevier. https://doi.org/10.1016/B978-0-12-801122-5.00020-9
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Monitoring Global Structural Changes and Specific Metal-Ion-Binding Sites in RNA by In-line Probing and Tb(III) Cleavage In C. Waldsich (Ed.), RNA Folding (No. 1086; Vol. 1086, pp. 143–158). Springer. https://doi.org/10.1007/978-1-62703-667-2_8
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Dissertation
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Studies on Mg$^{2+}$ and coenzyme B$_{12}$ induced conformational changes in coenzyme B$_{12}$ Riboswitches from E. coli and D. hafniense (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-165185
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2013
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Journal Article
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Distance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences Nucleic Acids Research, 41, 7453–7461. https://doi.org/10.1093/nar/gkt476
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