Publications
ZORA Publication List
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Publications
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2013
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Journal Article
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Kinetic subpopulations detected by single-molecule spectroscopy: fundamental property of functional nucleic acids or experimental artefact? Chimia, 67, 240–243. https://doi.org/10.2533/chimia.2013.240
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A QM/MM refinement of an experimental DNA structure with metal-mediated base pairs Journal of Inorganic Biochemistry, 127, 203–210. https://doi.org/10.1016/j.jinorgbio.2013.03.009
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The structural stabilization of the K three-way junction by Mg(II) represents the first step in the folding of a group II intron Nucleic Acids Research, 41, 2489–2504. https://doi.org/10.1093/nar/gks1179
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Hexaamminecobalt(III) - Probing metal ion binding sites in nucleic acids by NMR spectroscopy Zeitschrift Für Anorganische Und Allgemeine Chemie, 639, 1313–1320. https://doi.org/10.1002/zaac.201300123
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Helicase-mediated changes in RNA structure at the single-molecule level RNA Biology, 10, 133–148. https://doi.org/10.4161/rna.23507
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Diversity of cobalamin riboswitches in the corrinoid-producing organohalide respirer Desulfitobacterium hafniense Journal of Bacteriology, 195, 5186–5195. https://doi.org/10.1128/JB.00730-13
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Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction Angewandte Chemie Internationale Edition, 52, 11513–11516. https://doi.org/10.1002/anie.201305079
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Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction Angewandte Chemie, 125, 11727–11730. https://doi.org/10.1002/ange.201305079
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Structure and conformational dynamics of the domain 5 RNA hairpin of a bacterial group II Intron revealed by solution NMR and molecular dynamics simulations Biochemistry, 52, 7099–7113. https://doi.org/10.1021/bi400784r
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BOBA FRET: Bootstrap-based analysis of single-molecule FRET data PLoS ONE, 8, e84157. https://doi.org/10.1371/journal.pone.0084157
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Book Section
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Metal ion interactions with nucleic acids and their constituents In J. Reedijk & K. Poepelmeier (Eds.), Comprehensive Inorganic Chemistry (pp. 623–660). Elsevier. https://doi.org/10.1016/B978-0-08-097774-4.00317-X
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Complex formation of cadmium with sugar residues, nucleobases, phosphates, nucleotides, and nucleic acids In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Cadmium: From Toxicity to Essentiality (No. 11; Vol. 11, pp. 191–274). Springer. https://doi.org/10.1007/978-94-007-5179-8_8
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Ribozymes In S. Maloy & K. Hughes (Eds.), Brenner’s Encyclopedia of Genetics (pp. 254–258). Elsevier. https://doi.org/10.1016/B978-0-12-374984-0.01340-1
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Dissertation
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Studies on the stabilization of RNA structures through metal ions, ion-π interactions and metallo-supramolecular helicates (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-91034
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Tumor targeting with B12 scaffold, a coordination chemistry approach (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-90845
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2012
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Journal Article
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Unusually high-affinity Mg2+ binding at the AU-rich sequence within the antiterminator hairpin of a Mg2+ riboswitch Chemistry & Biodiversity, 9, 2035–2049. https://doi.org/10.1002/cbdv.201200031
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Single molecule FRET characterization of lage ribozyme folding Methods in Molecular Biology, 227–252. https://doi.org/10.1007/978-1-61779-545-9_15
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Accurate analysis of Mg2+ binding to RNA: From classical methods to a novel iterative calculation procedure Coordination Chemistry Reviews, 256, 279–288. https://doi.org/10.1016/j.ccr.2011.08.009
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MINAS-a database of Metal Ions in Nucleic AcidS Nucleic Acids Research, 40, D434–D438. https://doi.org/10.1093/nar/gkr920
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NMR spectroscopy in bioinorganic chemistry Chimia, 66, 791–797. https://doi.org/10.2533/Chimia.2012.791
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Metal Ion-RNA interactions studied via multinuclear NMR Methods in Molecular Biology, 253–274. https://doi.org/10.1007/978-1-61779-545-9_16
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Book Section
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Metal Ion-Promoted Conformational Changes of Oligonucleotides In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Interplay between Metal Ions and Nucleic Acids (Vol. 10, pp. 103–118). Springer. https://doi.org/10.1007/978-94-007-2172-2_3
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Characterization of metal ion-nucleic acid interactions in solution In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Interplay between Metal Ions and Nucleic Acids: Metal Ions in Life Science (No. 10; Vol. 10, pp. 1–42). Springer. https://doi.org/10.1007/978-94-007-2172-2_1
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2011
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Journal Article
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Probing the metal-ion-binding strength of the hydroxyl group Chemical Reviews, 111, 4964–5003. https://doi.org/10.1021/cr100415s
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Stability and Structure of Mixed-Ligand Metal Ion Complexes That Contain Ni(2+), Cu(2+), or Zn(2+), and Histamine, as well as Adenosine 5 `-Triphosphate (ATP(4-)) or Uridine 5 `-Triphosphate (UTP(4-)): An Intricate Network of Equilibria Chemistry, 17, 5393–5403. https://doi.org/10.1002/chem.201001931
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The change of corrin-amides to carboxylates leads to altered structures of the B(12)-responding btuB riboswitch Chemical Communications, 47, 403–405. https://doi.org/10.1039/c0cc02447c
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Book Section
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Multiple roles of metal ions in large ribozymes In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Structural and Catalytic Roles of Metal Ions in RNA (No. 9; pp. 197–234). Royal Society of Chemistry. https://doi.org/10.1039/9781849732512-00197
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Methods to detect and characterize metal ion binding sites in RNA In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Structural and Catalytic Roles of Metal Ions in RNA (No. 9; Vol. 9, pp. 37–100). RSC Publishing. https://doi.org/10.1039/9781849732512-00037
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2010
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Journal Article
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Controlling ribozyme activity by metal ions Current Opinion in Chemical Biology, 14, 269–275. https://doi.org/10.1016/j.cbpa.2009.11.024
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A lecture tour through Hungary Chimia, 64, 333.
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A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites Accounts of Chemical Research, 43, 974–984. https://doi.org/10.1021/ar900197y
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Metal ion-N7 coordination in a ribozyme branch domain by NMR Journal of Inorganic Biochemistry, 104, 611–613. https://doi.org/10.1016/j.jinorgbio.2010.01.008
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Shaping RNA structures with metal ions and metal ion complexes Chimia, 64, 126–131. https://doi.org/10.2533/chimia.2010.126
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Solution structure of a DNA double helix with consecutive metal-mediated base pairs Nature Chemistry, 2, 229–234. https://doi.org/10.1038/NCHEM.512
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Edited Scientific Work
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Organometallics in environment and toxicology (2010). In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Organometallics in Environment and Toxicology (Vol. 7, pp. 575-pp). Royal Society of Chemistry.
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2009
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Journal Article
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Exploring Metal Ion Coordination to Nucleic Acids by NMR Chimia, 63, 146–152. https://doi.org/10.2533/chimia.2009.146
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Buchbesprechung: Vanadium: the versatile metal / hrsg. von Kenneth Kustin, João Costa Pessoa, and Debbie C. Crans. American Chemical Society, Washington DC, 2007 Angewandte Chemie Internationale Edition, 121, 1920–1921. https://doi.org/10.1002/ange.200900230
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Book review: Nucleic acid-metal ion interactions, Nicholas V. Hud, RSC Publishing, 2009 Chemistry World, 6, 60–61. http://www.rsc.org/chemistryworld/
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Ca2+ induces the formation of two distinct subpopulations of group II intron molecules Angewandte Chemie Internationale Edition, 48, 9739–9742. https://doi.org/10.1002/anie.200903809
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Book review: Vanadium: the versatile metal / edited by Kenneth Kustin, João Costa Pessoa, and Debbie C. Crans. American Chemical Society, Washington DC, 2007 Angewandte Chemie Internationale Edition, 48, 1888–1889. https://doi.org/10.1002/anie.200900230
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Influence of decreased solvent permittivity on the structure and magnesium(II)-binding properties of the catalytic domain 5 of a group II intron ribozyme Inorganica Chimica Acta, 362, 771–776. https://doi.org/10.1016/j.ica.2008.03.095
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Book Section
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Metallothioneins in plants In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Metallothioneins and related chelators (No. 5; Vol. 5, pp. 107–153). Royal Society of Chemistry. https://doi.org/10.1039/9781847559531-00107
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Structure and Function of Vertebrate Metallothioneins In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Metallothioneins and Related Chelators (No. 5; pp. 279–318). Royal Society of Chemistry. https://doi.org/10.1039/9781847559531-00279
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Metallothionein-3, Zinc, and Copper in the Central Nervous System In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Metallothioneins and Related Chelators (No. 5; pp. 319–352). Royal Society of Chemistry. https://doi.org/10.1039/9781847559531-00319
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2008
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Journal Article
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Single molecule studies of group II intron ribozymes Proceedings of the National Academy of Sciences of the United States of America, 105, 13853–13858. https://doi.org/10.1073/pnas.0804034105
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Comparison of the acid-base properties of ribose and 2’-deoxyribose nucleotides. Chemistry, 14, 6663–6671. https://doi.org/10.1002/chem.200800496
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Divalent Metal Ions Tune the Self-Splicing Reaction of the Yeast Mitochondrial Group II Intron Sc.ai5γ Journal of Biological Inorganic Chemistry, 13, 1025–1036. https://doi.org/10.1007/s00775-008-0390-7
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The corrin moiety of coenzyme B12 is the determinant for switching the btuB riboswitch of E. coli Chembiochem, 9, 1408–1414. https://doi.org/10.1002/cbic.200800099
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In the footsteps of Alfred Werner: The institute of Inorganic Chemistry at the University of Zurich Chimia, 62, 111–113. https://doi.org/10.2533/chimia.2008.111
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Using in vitro transcription to construct scaffolds for one-dimensional arrays of mercuric ions Journal of Inorganic Biochemistry, 102, 1141–1151. https://doi.org/10.1016/j.jinorgbio.2007.12.023
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Divalent metal ions promote the formation of the 5′-splice site recognition complex in a self-splicing group II intron Journal of Inorganic Biochemistry, 102, 2147–2154. https://doi.org/10.1016/j.jinorgbio.2008.08.006
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Graduate School of Chemical and Molecular Sciences Zurich (CMSZH) Chimia, 62, 130–131. https://doi.org/10.2533/chimia.2008.130
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Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link Chemistry, 14, 3100–3109. https://doi.org/10.1002/chem.200701491
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Book Section
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Metal ion-nucleic acid interactions In S. Müller (Ed.), Nucleic acids from A to Z (pp. 149–151). Wiley-VCH.
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Dissertation
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The effect of metal ions on splice site formation of group II intron ribozymes (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-16679
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Metal ion binding to group II intron ribozymes: a study from bulk to the single molecule level (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-16674
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Edited Scientific Work
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2007
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Journal Article
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Metal-Ion-Coordinating Properties of the Dinucleotide 2′-Deoxyguanylyl(5′→3′)-2′-deoxy-5′-guanylate (d(pGpG)3−): Isomeric Equilibria Including Macrochelated Complexes Relevant for Nucleic Acids Chemistry, 13, 1804–1814. https://doi.org/10.1002/chem.200600744
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Solution Structure of Domain 6 from a Self-Splicing Group II Intron Ribozyme: A Mg2+ Binding Site is Located Close to the Stacked Branch Adenosine Chembiochem, 8, 306–314. https://doi.org/10.1002/cbic.200600459
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Determination of the Intrinsic Affinities of Multiple Site-Specific Mg2+Ions Coordinated to Domain 6 of a Group II Intron Ribozyme† Inorganic Chemistry, 46, 11224–11234. https://doi.org/10.1021/ic701627t
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Binding Interaction of [Re(H2O)3(CO)3]+ with the DNA Fragment d(CpGpG) Inorganic Chemistry, 46, 10458–10460. https://doi.org/10.1021/ic701647m
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Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry Chemical Reviews, 107, 97–113. https://doi.org/10.1021/cr0502605
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Towards the synthesis of light-stable coenzyme B12 analogs Inorganica Chimica Acta, 360, 360–368. https://doi.org/10.1016/j.ica.2006.07.103
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From nucleotides to ribozymes — A comparison of their metal ion binding properties Coordination Chemistry Reviews, 251, 1834–1851. https://doi.org/10.1016/j.ccr.2007.03.008
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Intimate Relationships between Metal Ions and Nucleic Acids Angewandte Chemie Internationale Edition, 46, 654–656. https://doi.org/10.1002/anie.200605065
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Book Section
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Complex Formation of Nickel(II) with Sugar Residues, Nucleobases,Phosphates, Nucleotides, and Nucleic Acids In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Nickel and Its Surprising Impact in Nature: Metal Ions in Life Sciences (No. 2; pp. 109–180). Wiley-Blackwell Publishing, Inc. https://doi.org/10.1002/9780470028131.ch4
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Edited Scientific Work
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Metal Ions in Life Sciences (Vols. 1–4). John Wiley & Sons Ltd. http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0470513241.html
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2006
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Journal Article
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Acid–base properties of the nucleic-acid model 2′-deoxyguanylyl(5′→3′)-2′-deoxy-5′-guanylate, d(pGpG)3–, and of related guanine derivatives Organic & Biomolecular Chemistry, 4, 1085–1090. https://doi.org/10.1039/b517904a
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Pyrazine as a building block for molecular architectures with PtII Inorganic Chemistry, 45, 2093–2099. https://doi.org/10.1021/ic051966k
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2005
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Journal Article
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Acid-base and metal-ion binding properties of the RNA dinucleotide uridylyl-(5’-->3’)-[5’]uridylate (pUpU3-). Chemistry, 11, 4163–4170. https://doi.org/10.1002/chem.200500013
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Structure Determination of Catalytic RNAs and Investigations of Their Metal Ion-Binding Properties Chimia, 59, 817–821. https://doi.org/10.2533/000942905777675534
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In vitro Transcription and Purification of RNAs of Different Size Chimia, 59, 812–816. https://doi.org/10.2533/000942905777675589
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Group II Intron Ribozymes and Metal Ions - A Delicate Relationship European Journal of Inorganic Chemistry, 2005, 2281–2292. https://doi.org/10.1002/ejic.200401007
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Edited Scientific Work
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Metal Ions in Biological Systems (Vols. 43–44). Taylor & Francis. http://www.taylorandfrancis.com/books/series/IHCMEIOBISY/
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2004
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Journal Article
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Two metal ions coordinated to a purine residue tolerate each other well Angewandte Chemie Internationale Edition, 43, 3793–3795. https://doi.org/10.1002/anie.200453987
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Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif Nature Structural & Molecular Biology, 11, 187–192. https://doi.org/10.1038/nsmb717
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2003
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Book Section
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The Lanthanides and Their Interrelations with Biosystems In A. Sigel & H. Sigel (Eds.), Metal Ions in Biological Systems (No. 40; pp. 477–512). Marcel Dekker, Inc.
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2002
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Journal Article
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N1 and N3 linkage isomers of neutral and deprotonated cytosine with trans-[(CH3NH2)2PtII] Chemistry, 8, 4681–4692. https://doi.org/10.1002/1521-3765(20021018)8:20<4681::AID-CHEM4681>3.0.CO;2-P
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Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes Inorganica Chimica Acta, 339, 355–365. https://doi.org/10.1016/S0020-1693(02)00962-3
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2001
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Journal Article
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Pt(II) Binding to N1 of Cytosine: Strengthening the Watson-Crick Pair with Guanine and yet Confining Its pH Existence Range Angewandte Chemie Internationale Edition, 40, 3397–3399. https://doi.org/10.1002/1521-3773(20010917)40:18<3397::AID-ANIE3397>3.0.CO;2-4
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Metal-modified nucleobase sextet: joining four linear metal fragments (trans-a2PtII) and six model nucleobases to an exceedingly stable entity. Chemistry, 7, 1968–1980. https://doi.org/10.1002/1521-3765(20010504)7:9<1968::AID-CHEM1968>3.0.CO;2-B
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2000
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Journal Article
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Metal ion binding sites in a group II intron core. Nature Structural Biology, 7, 1111–1116. https://doi.org/10.1038/81958
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Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with cytosine: platinum coordination strengthens the Watson-Crick pair. Journal of Biological Inorganic Chemistry, 5, 287–289. https://doi.org/10.1007/PL00010657
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Heavy metal mutagenicity: insights from bioinorganic model chemistry. Journal of Inorganic Biochemistry, 79, 261–265. https://doi.org/10.1016/S0162-0134(99)00179-8
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1999
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Monograph
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Effect of platinum(II) coordination on the acid-base and hydrogen-bonding properties of nucleobases: association patterns in solution and the solid state Logos Verlag. http://www.logos-verlag.de/cgi-bin/engbuchmid?isbn=296&lng=eng&id=
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1998
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Journal Article
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If Watson–Crick and Hoogsteen sites of guanine are blocked, hydrogen bonding with cytosine is via N2 and N3 Chemical Communications, 219–220. https://doi.org/10.1039/a704837h
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1997
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Journal Article
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Stabilities and structures of metal ion complexes of adenosine 5‘-o-thiomonophosphate (AMPS2-) in comparison with those of its parent nucleotide (AMP2-) in aqueous solution Journal of the American Chemical Society, 119, 744–755. https://doi.org/10.1021/ja962970l
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Acid-Base Properties of Adenosine 5′-O-Thiomonophosphate in Aqueous Solution Chemistry, 3, 29–33. https://doi.org/10.1002/chem.19970030106
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