Bioinorganic Chemistry and Crystallography in the Spingler group

We are working in two research areas: Bioinorganic Chemistry and Method Development of Single Crystal Growth.

In the field of Bioinorganic Chemistry, we work towards a more efficient Photodynamic Therapy (PDT). Previously, we have synthesized novel nanometer sized porphyrin-platinum conjugates. They display excellent light toxicity when irradiated with visible light, but essentially no dark toxicity against various human cancer cell lines. The platinum complexes are characterized by a high singlet oxygen quantum yield, an excellent light to dark toxicity ratio (>8300) and IC50 values upon irradiation with red irradiation (750 nm LED light) down to 6 nM.

Part of the group currently studies innovative ways of improving the crystallization of small molecules, which can also be used for the salt screening of active pharmaceutical ingredients (API).