Research in the Spingler group

Novel reagents for Photodynamic Therapy

Photodynamic Therapy (PDT) is a rather new method in medicine. After administration of a photosensitizer (PS) to the patient and the localisation of the photosensitizer in the tissue of interest, light is focused onto the intended area of treatment (normally close to a surface). An intensive, artificial light source transforms the PS into its excited state which then decays upon generation of

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Summary of Angew. Chem. Int. Ed. 2014, 53, 6938

radical oxygen species that kill the surrounding tissue. By chosing the area which is irradiated with the laser light, precise spaticial control of the tissue to be destroyed can be achieved.

We have studied novel conjugates of platinum bound to a porphyrin that are extremely toxic to cancer cells upon light irradiation but are essentially non-toxic in the dark. This very good system could be even improved by insertation of zinc into the porphyrin yielding excellent ratios of dark to light toxicity.

Crystallography of small and non-small molecules

We have published a tutorial about the single crystal growth of small molecules (see pictures with an example for the optimisation of crystallization by vapor diffusion below). Currently, we develop innovative methods of improving the crystallization of organic salt, which can also be used for the salt screening of active pharmaceutical ingredients (API) or metal complexes. Furthermore we study DNA, RNA and protein molecules by crystallography.

 

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Example from CrystEngComm, 2012, 14, 751