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Department of Chemistry Sigel Lab

Kasimir Kienbeck

Kasimir Kienbeck

Phone
+41 44 63 54648
Room number
Y19-K-46

Research project

I am intrigued by small RNAs which catalyze chemical reactions: ribozymes. Though highly abundant and well characterized in vitro, biological relevance has only been assigned to a few examples. After discovering small ribozymes that cleave tRNA trailers, I aim to solve their structure via cryo-EM employing nanostructure assembly and grafting approaches. I hope to elucidate the molecular details of the ribozyme self-scission mechanism and contribute to the fascinating field of RNA catalysis.

Behind the Lab Coat: My Inspirations and Passions

Year you joined the Sigel Lab: 2022
Favorite molecule: Adenosine Triphsophate
Scientist hero: Richard Feynman
Favorite restaurant, coffee shop, or place in Zurich: Schanzengraben in summer, any Cafe in winter
If I could visit anywhere, I would go to: Moon
Class or teacher that changed my life/inspired me: Middle school chemistry teacher
Outside of the lab, I enjoy good food, playing the guitar, and going to the gym.

Education

01/2022 - present Doctorate in Chemical and Molecular Sciences
Supervisor: Prof. Roland K. O. Sigel, Susann Zelger-Paulus
09/2012 - 05/2016 Master of Science in Molecular Microbiology, Microbial Ecology and Immunobiology
Thesis: "Characterization of RNAP Binding Aptamer that Activate Transcription in E. Coli "
Department of Biochemistry, University of Vienna, Austria
09/2010 - 11/2012 Bachelor of Science in Molecular Biotechnology
Department of Applied Life Sciences, FH Campus Wien, Austria 

Professional Experience

09/2016 - 10/2021
Chemist in Research and Development
Development of temperature label prototypes and upscaling to serial production Innorese AG, Switzerland
05/2015 - 07/2015
Research Exchange within the scope of master's thesis
Department of Integrated Structural Biology, IGBMC, France
09/2013 - 01/2014
Erasmus Internship within the scope of master's degree studies
Department of Biology, University of Copenhagen, Denmark
01/2012 - 07/2012
Erasmus Internship as bachelor trainee
Department of Genetics, Microbiology and Toxicology, Stockholm University, Sweden