Research Project
Group II introns are large self-splicing ribozymes that have been extensively studied, providing critical insights into RNA splicing mechanisms and potential therapeutic applications. While crystal structures provide valuable static snapshots of their architecture, they do not capture the dynamic structural rearrangements that occur during catalysis. To address this, we use single-molecule Förster resonance energy transfer (smFRET) to track RNA dynamics in real time, providing a deeper understanding of their structural transitions and interactions. Our research demonstrates the power of smFRET in the study of RNA function.
Behind the Lab Coat: My Inspirations and Passions
Year you joined the Sigel Lab: 2023
Scientist hero: Manu Prakash
Class or teacher that inspired me: High School English Language teacher.
Outside of the lab, I enjoy watching and playing football.
Education
| Since 2023 | PhD in the group of Prof. Roland K. O. Sigel |
| 2017 – 2022 | Integrated BS-MS (Bachelor of Science - Master of Science), with Biology Major, Indian Institute of Science Education and Research, Tirupati |
| 2014 – 2016 | Higher Secondary Education Gov. Higher Secondary School Venjaramoodu, Kerala, India |
Professional experience
| 05/2021 - 4/2022 |
Master Thesis project, Single Molecule Biophysics Lab |
| 01/2021 – 04/2021 |
Semester Project, Single Molecule Biophysics Lab |
| 05/2019 – 06/2019 |
Summer Internship, CSIR - NIIST, Thiruvananthapuram, India |